"Activable" nanomedicine precision chemotherapy does not hurt the body April 19, 2018 Source: Science and Technology Daily Traditional tumor chemotherapy methods, normal tissue cells will also be "injury", aggravating patient suffering. Recently, the reporter learned from Nankai University that the Guo Dongsheng team of the School of Chemistry and the Ding Dan team of the College of Life Sciences jointly developed a “activatable†nano drug for cancer chemotherapy based on the subject-object chemistry concept, which overcomes the traditional photosensitizer lack of tumor targets. The directionality, the phototoxicity of normal tissues and other defects, successfully achieved animal tumor selective imaging and targeted therapy. Relevant results are also published in the new issue of the top journal, the American Chemical Society. According to reports, photodynamic therapy is becoming one of the important means of cancer treatment because of its small trauma and simple operation. Photodynamic therapy requires the addition of photosensitizers to the human body. Traditional photosensitizers are phototoxic to normal human tissues, making them extremely limited in clinical applications. How to improve the existing commercial photosensitizer has become a worldwide problem in recent years, and the "activatable" photosensitizer for tumor treatment has also attracted the attention of the medical community. Guo Dongsheng, a research group of the School of Chemistry, Nankai University, based on the research on the supramolecular diagnosis and treatment of calixarene, creatively proposed a new strategy of “biomarker replacement activationâ€. Starting from mature commercial photosensitizers, amphiphilic calixarees and The photosensitizer combination method, through the interaction of host and guest, constructed a novel nano drug carrier of amphiphilic calixarene. After the chemistry theory was verified, the Ding Dan team of the School of Life Sciences of Nankai University relayed the strategy to the imaging and treatment of living tumors. The research group injected nanomedicine into the tumor-bearing nude mice by tail vein administration. When the photosensitizer was encapsulated in the main cavity, its fluorescence imaging ability and photoactivity were almost completely quenched; when the nano drug was transported to In the tumor tissue area, the photosensitizer is displaced from the cavity and reactivates its original photophysical properties, thereby enabling tumor selective imaging and targeted therapy. (Reporter Sun Yusong correspondent Ma Chao) Peeled Garlic,Peeled Garlic Cloves,Pre Peeled Garlic,Peeled Black Garlic shandong changrong international trade co.,ltd. , https://www.changronggarliccn.com