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Product Name: Tenofovir
Synonyms: 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid;D,L-TENOFOVIR;TENOFOVIR;(R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE;(R)-9-(2-Phosphonomethoxypropyl)Adenine;Tenofovir(ForResearchOnly);(R)-PMPA;[[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid
CAS: 147127-20-6
MF: C9H14N5O4P
MW: 287.21
Product Categories: Purine;ACTIVE PHARMACEUTICAL INGREDIENTS;Nucleotides and Nucleosides;Bases &Â Related Reagents;Intermediates &Â Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Inhibitors
Melting point  276-280°CÂ
Storage temp.  Store at -20°C
Chemical Properties White Crystalline SolidÂ
Usage Acyclic phosphonate nucleotide analogue. Used as an anti-HIV agentÂ
Usage Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.Â
Usage Tenofovir blocks reverse transcriptase and hepatitis BÂ virus infections.Â
Tenofovir Usage And Synthesis
1. Antiviral drugs, Tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. The active substance is Tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut.
2. Tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human DNA. It is the first nucleotide analogs to treat HIV-1 infection that approved by the US Food and Drug Administration (FDA).
3. Tenofovir is a main medicine in AIDS cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human AIDS virus).
Tenofovir PharmacokineticsÂ
Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h .
Indications: Tenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis BÂ treatment .
Tenofovir Adverse effects
1. The most common side effects associated with Tenofovir include asthenia.
2. Tenofovir has also been implicated in mild to moderate gastrointestinal reactions such as nausea, vomiting, diarrhea, and asthenia. Less frequent side effects include hepatotoxicity, abdominal pain, and flatulence,bloating, lactic acidosis, hepatomegaly with fatty liver, pancreatitis and so on. these adverse effects are common with the use of nucleoside analogues either separately or when combined with other drugs.
3. Tenofovir can also lead to metabolic system hypophosphatemia (1% incidence); fat accumulation and redistribution, including central obesity, buffalo hump, peripheral wasting, breast enlargement, Cushing syndrome.
4. Tenofovir may cause lactic acidosis, hepatomegaly with steatosis-related and so on.
5. Tenofovir may make nervous system: dizziness, headache.
6. Tenofovir sometimes leads to respiratory system: dyspnea.
7. Tenofovir may cause skin herpes.
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White Powder Pharmaceutical Raw Materials Tenofovir For Antiviral CAS 147127-20-6
Product Name: Tenofovir
Synonyms: 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid;D,L-TENOFOVIR;TENOFOVIR;(R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE;(R)-9-(2-Phosphonomethoxypropyl)Adenine;Tenofovir(ForResearchOnly);(R)-PMPA;[[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid
CAS: 147127-20-6
MF: C9H14N5O4P
MW: 287.21
Product Categories: Purine;ACTIVE PHARMACEUTICAL INGREDIENTS;Nucleotides and Nucleosides;Bases &Â Related Reagents;Intermediates &Â Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Inhibitors
Melting point  276-280°CÂ
Storage temp.  Store at -20°C
Chemical Properties White Crystalline SolidÂ
Usage Acyclic phosphonate nucleotide analogue. Used as an anti-HIV agentÂ
Usage Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.Â
Usage Tenofovir blocks reverse transcriptase and hepatitis BÂ virus infections.Â
Tenofovir Usage And Synthesis
1. Antiviral drugs, Tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. The active substance is Tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut.
2. Tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human DNA. It is the first nucleotide analogs to treat HIV-1 infection that approved by the US Food and Drug Administration (FDA).
3. Tenofovir is a main medicine in AIDS cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human AIDS virus).
Tenofovir PharmacokineticsÂ
Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h .
Indications: Tenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis BÂ treatment .
Tenofovir Adverse effects
1. The most common side effects associated with Tenofovir include asthenia.
2. Tenofovir has also been implicated in mild to moderate gastrointestinal reactions such as nausea, vomiting, diarrhea, and asthenia. Less frequent side effects include hepatotoxicity, abdominal pain, and flatulence,bloating, lactic acidosis, hepatomegaly with fatty liver, pancreatitis and so on. these adverse effects are common with the use of nucleoside analogues either separately or when combined with other drugs.
3. Tenofovir can also lead to metabolic system hypophosphatemia (1% incidence); fat accumulation and redistribution, including central obesity, buffalo hump, peripheral wasting, breast enlargement, Cushing syndrome.
4. Tenofovir may cause lactic acidosis, hepatomegaly with steatosis-related and so on.
5. Tenofovir may make nervous system: dizziness, headache.
6. Tenofovir sometimes leads to respiratory system: dyspnea.
7. Tenofovir may cause skin herpes.
 More products you may like
Sulbutiamine CAS 3286-46-2
Aniracetam CAS 72432-10-1
Noopept CAS 157115-85-0
Idra-21 CAS 22503-72-6
4-Aminobutyric acid CAS 56-12-2
NSI-189 Free Base CAS 1270138-40-3
NSI-189 Phosphate CAS 1270138-41-4
9-fluorenol CAS 1689-64-1
Coluracetam CAS 135463-81-9
Sunifiram CAS 314728-85-3
Pramiracetam CAS 68497-62-1
Piracetam CAS 7491-74-9
Oxiracetam CAS 62613-82-5
Fasoracetam CAS 110958-19-5
Nefiracetam CAS 77191-36-7
Centrophenoxine CAS 3685-84-5
Pikamilon Sodium CAS 62936-56-5
PRL-8-53 HCL CAS :Â 51352-87-5
Â
Levodopa(L-DOPA) CAS :Â 59-92-7
Etiracetam(UCB-6474) CAS :Â 33996-58-6
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White Powder Pharmaceutical Raw Materials Tenofovir for Antiviral CAS 147127-20-6
Model NO.: 147127-20-6
Delivery: 3-5 Days 100%Door to Door
Appearance: White Crystalline Powder
Polciy: Re-Shipping Policy
Shipment: EMS, FedEx, TNT, DHL, UPS
Payment: Western Union, Moneygram, T/T, Bitcoin
Trademark: WHSO
Transport Package: 25kg/Drum
Specification: 1kg/25kg/package
Origin: China
HS Code: 293729002
Model NO.: 147127-20-6
Delivery: 3-5 Days 100%Door to Door
Appearance: White Crystalline Powder
Polciy: Re-Shipping Policy
Shipment: EMS, FedEx, TNT, DHL, UPS
Payment: Western Union, Moneygram, T/T, Bitcoin
Trademark: WHSO
Transport Package: 25kg/Drum
Specification: 1kg/25kg/package
Origin: China
HS Code: 293729002
White Powder Pharmaceutical Raw Materials Tenofovir For Antiviral CAS 147127-20-6