Release date: 2008-01-02 New device for malaria testing in Canada A research team at the Department of Physical Chemistry at McGill University in Canada has developed a new method for detecting malaria infections in human blood using laser and nonlinear optics. Researchers believe that this new technology can make the detection of malaria parasites in the blood easier and less laborious. The research report was published in the December 20 issue of Biophysics.
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Malaria is a disease transmitted by carriers that spreads by parasites of the malaria parasite type, mostly in tropical and subtropical regions. At present, there are 350 to 500 million cases reported every year in the world, which has caused 1 million to 3 million deaths. Most deaths occur in sub-Saharan Africa where medical resources are scarce.
The new method developed by McGill University uses the "third harmonic" generation (THG) optical effect. Under this effect, the Plasmodium pigment secreted by the parasite emits blue light under the irradiation of an infrared laser. Researcher Dr. Weisman said that, like the familiar music and sound, it is a multiple of the fundamental sound frequency. The nonlinear optical effect is similar, and if you apply a strong laser beam of a specific frequency to a specific material, a multiplier harmonic is generated. Plasmodium pigments produce a large nonlinear optical response to the third harmonic, which emits blue light. Current testing techniques require skilled technicians to sample the test glass and look for the DNA characteristics of the parasite under the microscope, and then manually calculate the number of all visible infected cells, the process depending on the technical proficiency of the inspector.
The university's researchers hope to use the existing mature fiber optic communication lasers and fluorescent cells to push the method from the laboratory to practical use as soon as possible. They hope to design an integrated device for use in hospitals in countries where epidemics are endemic. Hospital staff can inject cell samples directly into the device, and the device automatically calculates the number of infected cells without manual intervention. ——Shanghai Medical Device Industry Association
