ETR Medical Nurse Calling System is designed for providing the communication between patients in wards and medical personnel in nurses offices in case of any peculiar conditions in hospitals. With cast-into-once deluxe plastic master telephone hosing, innovative summary fixed mode, complete information electronic summary and audio number reporting system,it has higher performance-cost ration than those products of the same variety. So far, two-wire and four-wire systems are available.
Superiority of Hospital Nurse Calling System:
Select-able: More beds quantity choices: 30, 50, 70, 110 beds.
Warranty: We offer a full year`s warranty, on going maintenance and provide the installation on-site if required.
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Immunoglobulin (IgG) clinical relevance and detection reagents
Immunoglobulin (IgG) is the main molecule of human immunity, accounting for 75% of the total amount of immunoglobulin in healthy human plasma. Human IgG is divided into four different subtypes: IgG1, IgG2, IgG3, IgG4. The relative serum concentration of the human IgG subtype is IgG1>IgG2>IgG3>IgG4. The four IgG subtypes have the same amino acid sequence of 95% or more in the heavy chain constant region, and the amino acid composition and structure in the hinge region are significantly different. This region is located between the Fab arm and the C-terminus of the two heavy chains (CH2 and CH3), which determines the variability of the IgG acting molecule. In particular, the length and variability of the hinge region are different, and these differences in structure and variability are related to different functions of IgG, such as activation of complement and opsonization (ie, induction of phagocytic action). The function of these functions through the invariant region Fc fragment is due to the interaction of the antibody with the antigen at the Fab portion.
Clinical relevance
Abnormal IgG subtypes are manifestations of abnormal immune responses, and various diseases cause a decrease or increase in IgG subtypes. The most common consequence of the lack of an IgG subtype is the lack of humoral immunity, although this may not be clinically manifest. A decrease in the level of one of the IgG subtypes may be accompanied by an increase in the level of one or several other IgG subtypes such that the total IgG level is still normal. Therefore, even if the total amount of IgG is in the normal range or slightly below the normal range, it is necessary to determine the level of IgG subtype. Some studies have shown that the lack of selectivity for IgG subtypes is associated with disease, particularly in bronchiectasis, severe recurrent otitis media, sinusitis, pneumonia, and bronchitis. IgG2 deficiency is associated with pediatric respiratory recurrent infections and streptococcal pneumonia caused by inclusion body bacteria such as Haemophilus influenzae type B. This has led to an increase in the need to detect pediatric IgG subtypes.
The primary clinical indication for detecting IgG subtypes is that long-term or severe infections often occur and are not explained by general clinical and laboratory findings. In general, IgG subtypes should be tested when clinically suspected of having inadequate immune function.
Detection reagents and kits for determining human IgG subtype levels
There are various methods for quantitative detection of IgG subtypes. Sanquin's test kits and reagents, the most commonly used assays: radioimmunoassay (RID), ELISA, and nepholometry.
Sanquin's principle is that no matter which method, the values ​​measured from a certain serum sample should be the same, so Sanquin has a very good correlation with the various kits for detecting IgG subtypes.
The normal reference values ​​for IgG subtype serum concentrations at calibration were IgG1 5.0 g/L, IgG2 2.6 g/L, IgG3 0.5 g/L, IgG4 0.5 g/L (according to WHO 67/97 document).
IgG subtype detection quality control service
Sanqin Reagent provides quality control services for human IgG subtype assays, free of charge to any laboratory in the world, and provides three numbered samples (healthy and patient's serum) to laboratories participating in quality control inspections twice a year. The levels of IgG1, IgG2, IgG3, and IgG4 in these samples were determined by radioimmunoassay (RID), ELISA, and scatter nephelometer in each laboratory, and the results were sent to evaluation and mathematical statistics.
IgG subtype booklet
The Sanquin Reagents Department publishes a free booklet, Human IgG Subtypes: Diagnostic Indicators for Measuring Functions, which provides a comprehensive overview of the structure and function of human IgG subtypes, the role of clinical diagnosis, and current methods of detection.
Products that detect human IgG subtypes include the following kits and reagents
* Peliclass TM scatter nephelometer for kits and reagents for nephelometric assays.
* PeliRIDe TM radioimmunoprecipitation sedimentation technology, kits and reagents for radioimmunoassay, and antisera for immunoprecipitation.
* Peliclass TM enzyme-linked immunosorbent assay (ELISA), a test kit for "sandwich" enzyme immunoassays.
* Peliclass TM monoclonal antibodies, labeled and unlabeled monoclonal antibodies.
It consists of host,bed extension, corridor display, door lamp, secondary host as well as optional modules (including music, bathroom extension) for realizing some peculiar functions.
Precision: Simultaneous calling of multiple extensions without omission.
Credibility: ETR nurse call system provides reliable solutions for a wide range of customers including hospitals, care groups, health recovery center, nursing and residential homes.