Competitive Price Factory Direct CAS 134523-03-8 Atorvastatin Calcium

Competitive Price Factory Direct CAS 134523-03-8 Atorvastatin Calcium

CAS No.134523-03-8
Chemical Name:Atorvastatin calcium
SynonymsTahor;ci-981;YM-548;Sortis;LIPITOR;pd134298-38a;Atorvastatin c;ATORVASTATIN CA;Atorvastatin 3S,5S-Atorvastatin
CBNumber:CB4260130
Molecular Formula:C66H68CaF2N4O10
Formula Weight:1155.36
Atorvastatin calcium Properties
Melting point:176-178°C
storage temp. Store at +4°C
solubility DMSO: ≥10mg/mL



Indications and Usage:

Atorvastatin is a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Atorvastatin can lower the serum low-density lipoprotein cholesterol of some homozygous familial hypercholesterolemia patients, which is a population that rarely responds to other lipid-lowering drugs. It is clinically used to treat primary hypercholesterolemia, mixed hyperlipidemia, and hypertriglyceridemia, homozygous familial hypercholesterolemia, and it is used to prevent and treat atherosclerosis. Atorvastatin can also regulate blood lipids and combat atherosclerosis.

Mechanisms of Action:

Atorvastatin mainly inhibits HMGCoA reductase synthesis to inhibit cholesterol synthesis, reducing the amount of serum low-density lipoprotein cholesterol and triglycerides. Atorvastatin inhibits cells from synthesizing cholesterol, thus interrupting lipoprotein production, which causes serum total cholesterol levels to decrease, effectively lowers serum triglyceride levels, and increases serum high-density lipoprotein cholesterol levels.

Pharmacokinetics:

Rapidly absorbed after oral intake, reaches maximum blood concentration in 1-2 hours, and is not affected when taken with food. Its absolute bioavailability is about 12%, and its usage in inhibiting HMG-CoA reductase is about 30%. This low percentage is due to cleansing by gastrointestinal mucosa and the first round of metabolism in the liver. Its serum protein binding rate is above 98%. It is mainly metabolized in the liver by cytochrome P450 3A4, its metabolites are O-hydroxylate, its derivatives and various beta oxidants, and these o-hydroxylates are active against o-hydroxylate metabolites. This drug and its metabolites are metabolized in and/or out of the liver and excreted mainly in bile, and small amounts (less than 2% of dosage amount) is excreted through urine. This drug's average serum clearing half-life is 14 hours, and its active metabolites' half-life is 20-30 hours.

Uses:

A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

The quality control process:

1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

Our Advantages:

1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .

3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be recommanded for you.

4. Fast delivery: We have stock, so we can delivery quickly once payment is received.

5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.

6. Competitive prices: A discount would be given when you make a large order.

Competitive Price Factory Direct CAS 134523-03-8 Atorvastatin Calcium

CAS No.134523-03-8
Chemical Name:Atorvastatin calcium
SynonymsTahor;ci-981;YM-548;Sortis;LIPITOR;pd134298-38a;Atorvastatin c;ATORVASTATIN CA;Atorvastatin 3S,5S-Atorvastatin
CBNumber:CB4260130
Molecular Formula:C66H68CaF2N4O10
Formula Weight:1155.36
Atorvastatin calcium Properties
Melting point:176-178°C
storage temp. Store at +4°C
solubility DMSO: ≥10mg/mL



Indications and Usage:

Atorvastatin is a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Atorvastatin can lower the serum low-density lipoprotein cholesterol of some homozygous familial hypercholesterolemia patients, which is a population that rarely responds to other lipid-lowering drugs. It is clinically used to treat primary hypercholesterolemia, mixed hyperlipidemia, and hypertriglyceridemia, homozygous familial hypercholesterolemia, and it is used to prevent and treat atherosclerosis. Atorvastatin can also regulate blood lipids and combat atherosclerosis.

Mechanisms of Action:

Atorvastatin mainly inhibits HMGCoA reductase synthesis to inhibit cholesterol synthesis, reducing the amount of serum low-density lipoprotein cholesterol and triglycerides. Atorvastatin inhibits cells from synthesizing cholesterol, thus interrupting lipoprotein production, which causes serum total cholesterol levels to decrease, effectively lowers serum triglyceride levels, and increases serum high-density lipoprotein cholesterol levels.

Pharmacokinetics:

Rapidly absorbed after oral intake, reaches maximum blood concentration in 1-2 hours, and is not affected when taken with food. Its absolute bioavailability is about 12%, and its usage in inhibiting HMG-CoA reductase is about 30%. This low percentage is due to cleansing by gastrointestinal mucosa and the first round of metabolism in the liver. Its serum protein binding rate is above 98%. It is mainly metabolized in the liver by cytochrome P450 3A4, its metabolites are O-hydroxylate, its derivatives and various beta oxidants, and these o-hydroxylates are active against o-hydroxylate metabolites. This drug and its metabolites are metabolized in and/or out of the liver and excreted mainly in bile, and small amounts (less than 2% of dosage amount) is excreted through urine. This drug's average serum clearing half-life is 14 hours, and its active metabolites' half-life is 20-30 hours.

Uses:

A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

The quality control process:

1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

Our Advantages:

1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .

3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be recommanded for you.

4. Fast delivery: We have stock, so we can delivery quickly once payment is received.

5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.

6. Competitive prices: A discount would be given when you make a large order.