Release date: 2009-08-19 Food Additives,Natural Food Additives,Food Additive Saccharin,Popular Food Additives SHANDONG BAISHENG BIOTECHNOLOGY COM , https://www.baishengbioproducts.com
The Heidelberg University School of Medicine published a communique on August 12th that the researchers have developed a new technology that can better monitor lung diseases such as emphysema and chronic bronchitis, and has been successfully tested on experimental mice. In the future, it can be applied to human lung disease surveillance.
According to the announcement, lung macrophages produce excessive matrix metalloproteinase-12 (MMP-12) under constant smoking or other external stimuli, thereby damaging the alveolar structure and causing emphysema. Researchers from researchers at the University of Heidelberg School of Medicine have developed a fluorescent probe that uses fluorescence resonance energy transfer (FRET) to detect the activity of the MMP-12 enzyme to determine whether the lung is pathologically or not. Using this probe to detect rats with inflammation in the lungs, the researchers found that the MMP-12 enzyme activity on the surface of the lung macrophages did increase.
The researchers will next focus on simplifying this monitoring technique so that it can be operated in a common clinical diagnostic room, making the technology a complement to routine diagnostics for lung diseases such as lung X-rays. Researchers hope that the technology can also be used to monitor other enzymes involved in the lung inflammatory process to gain a deeper understanding of the causes of various lung diseases.
The research results have been published in the new issue of the British journal Nature and Chemical Biology. Shanghai Medical Device Industry Association