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Colorectal cancer is a common malignant tumor in humans, plaguing millions of patients around the world. Recently, US researchers have discovered a molecular interaction mechanism that leads to two signaling pathways in colorectal cancer. This finding will likely point to new research directions for better treatment of this cancer. Related research results were published in the November 15 issue of Cancer Research.
Vladimir Spiegelman, an associate professor of dermatology at the University of Wisconsin-Madison School of Medicine and Public Health, led a research team to study the cellular processes that led to several cancers. Recently, they have focused their research on the Wnt signaling pathway, and there is evidence that this signaling pathway is involved in most colorectal cancers.
Like all signaling pathways, the Wnt signaling pathway also involves a group of molecules that perform signal tasks at each step of the pathway, ie, to perform a particular cellular function until the pathway task is finalized. If any malfunction occurs during normal procedures, it can cause cancer.
The Spiegelman study found that the Wnt signaling pathway regulates a gene that promotes the conversion of normal colorectal cells into malignant cells, CRD-BP. In the Wnt signaling pathway, CRD-BP binds to a cancer-promoting transcription factor, GLI1, and increases its expression of messenger ribonucleic acid (mRNA). GLI1 is also very active in another signaling pathway, the Hedgehog signaling pathway. The Hedgehog signaling pathway is involved in the pathogenesis of several cancers, but its role in colorectal cancer has been controversial.
Scientists believe that these two signaling pathways can interact adjustment in different ways, but the mechanism of how and where they occur is unclear. And this is the goal of Spiegelman's research.
The team found that, CRD-BP in charge of the Wnt and Hedgehog two signaling pathways between the links. Such genes from the Wnt signaling pathway force acting on the Hedgehog signaling pathway, to stabilize and enhance the GLI1 mRNA expression. Regardless of the Hedgehog signaling pathway upstream of what happens, the situation will happen, and it happened not dependent on Hedgehog signaling.
Spiegelman noted increase GLIl, and then activate cancer-promoting genes, generally considered to be the target of the Hedgehog signaling pathway downstream. GLI1 itself can become potential drugs that block a good drug targets, but if the CRD-BP as a drug target, it will be more effective in influencing two different cell signaling pathways. Blocking this mechanism through drugs can prevent colorectal cancer affecting millions of people around the world. Meditech Medical Network