Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs

October 26, 2018

Model NO.: Regorafenib
Mf: C21h15clf4n4o3
MW: 482.81
CAS: 755037-03-7
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
Model NO.: Regorafenib
Mf: C21h15clf4n4o3
MW: 482.81
CAS: 755037-03-7
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs

Regorafenib Basic Info.
Synonyms:Regorafenib; 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
Molecular Weight:482.81
Molecular Formula:C21H15ClF4N4O3
Specification: 99%
CAS:755037-03-7 
Appearance: White to off-white powder
Introduction:It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs

Regorafenib Introduction:
Regorafenib is an oral multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Since 2009 it was studied as a potential treatment option in multiple tumor types.


Regorafenib Application
 
Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RETand TIE2.
Regorafenib is a multikinase inhibitor of both intracellular and membrane-bound RTKs. It shows potent inhibition of angiogenic and stromal RTKs like VEGF receptors-1-3, PDGFR-β and FGF receptor-1 with IC50 values ranging from4.2 to 311nM in biochemical assays. It also inhibits oncogenic RTKs, such as RET and c-KIT, with IC50 values ranging from 1.5 to 28nM in cellular assays.
 
Regrafenib is reported to have anti-tumor efficacy to various tumors including breast, pancreas, thyroid, melanoma, GIST, and CRC with a mean IC50 value less than 1μM. These inhibition effects of tumor growth are also found in mouse xenograft models after the treatment of regorafenib at dose ranging from 10 to 100 mg/kg.

Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs
MonoMethyl Dolastatin 10 203849-91-6
MMAE 474645-27-7
MMAF 745017-94-1
DM1 139504-50-0
Vandetanib 443913-73-3
nintedanib 656247-17-5
PF06463922 1454846-35-5
AZD6244/ Selumetinib 606143-52-6
INCB28060 606143-52-6
BKM120 944396-07-0 
AZD3759 1626387-80-1
AP26113 1197958-12-5
linifanib/ABT-869 796967-16-3
AZD9291 1421373-66-1
WZ4002 1213269-23-8
dacomitinib 1110813-31-4
crizotinib  877399-52-5
Regorafenib hydrate 1019206-88-2
regorafenib  755037-03-7
Imatinib Mesylate 220127-57-1
Argireline Acetate 616204-22-9


Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
3. How to cooperate with us?
You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email. 

Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept T/T  , Moneygram , Western Union.

Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8  How to proceed order?
Let me konw the items,quantity and the destination contury wihch help me to give you a right price
Please let me know the items you are looking for, quantity and the destination country.After you confirm all details of order, pay money 100% in advance and give us Shipping address.We arrange the shipment at first time after receive payment and offer after-sales service after you receive parcel.
Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs

 Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 antibody ADCs

Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs
  Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs

Regorafenib Basic Info.
Synonyms:Regorafenib; 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
Molecular Weight:482.81
Molecular Formula:C21H15ClF4N4O3
Specification: 99%
CAS:755037-03-7 
Appearance: White to off-white powder
Introduction:It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs

Regorafenib Introduction:
Regorafenib is an oral multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Since 2009 it was studied as a potential treatment option in multiple tumor types.


Regorafenib Application
 
Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RETand TIE2.
Regorafenib is a multikinase inhibitor of both intracellular and membrane-bound RTKs. It shows potent inhibition of angiogenic and stromal RTKs like VEGF receptors-1-3, PDGFR-β and FGF receptor-1 with IC50 values ranging from4.2 to 311nM in biochemical assays. It also inhibits oncogenic RTKs, such as RET and c-KIT, with IC50 values ranging from 1.5 to 28nM in cellular assays.
 
Regrafenib is reported to have anti-tumor efficacy to various tumors including breast, pancreas, thyroid, melanoma, GIST, and CRC with a mean IC50 value less than 1μM. These inhibition effects of tumor growth are also found in mouse xenograft models after the treatment of regorafenib at dose ranging from 10 to 100 mg/kg.

Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs
MonoMethyl Dolastatin 10 203849-91-6
MMAE 474645-27-7
MMAF 745017-94-1
DM1 139504-50-0
Vandetanib 443913-73-3
nintedanib 656247-17-5
PF06463922 1454846-35-5
AZD6244/ Selumetinib 606143-52-6
INCB28060 606143-52-6
BKM120 944396-07-0 
AZD3759 1626387-80-1
AP26113 1197958-12-5
linifanib/ABT-869 796967-16-3
AZD9291 1421373-66-1
WZ4002 1213269-23-8
dacomitinib 1110813-31-4
crizotinib  877399-52-5
Regorafenib hydrate 1019206-88-2
regorafenib  755037-03-7
Imatinib Mesylate 220127-57-1
Argireline Acetate 616204-22-9


Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
3. How to cooperate with us?
You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email. 

Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept T/T  , Moneygram , Western Union.

Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8  How to proceed order?
Let me konw the items,quantity and the destination contury wihch help me to give you a right price
Please let me know the items you are looking for, quantity and the destination country.After you confirm all details of order, pay money 100% in advance and give us Shipping address.We arrange the shipment at first time after receive payment and offer after-sales service after you receive parcel.
Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs

 Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 antibody ADCs

Anti-Tumor Efficacy Regorafenib CAS: 755037-03-7 Antibody Adcs
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