Release date: 2018-01-10 Many previous studies have shown that the gene encoding the Wnt signaling pathway transcription factor TCF7L2 is a very strong candidate for type 2 diabetes, but how this factor is involved in the development of type 2 diabetes has not been well understood. TCF7L2 protein is a key transcriptional effector of Wnt/β-catenin signaling pathway. Wnt/β-catenin signaling pathway can play a very important regulatory role in development. For the lipogenesis process, previous studies have shown that this signaling pathway plays a negative role. Regulation. However, the effect of TCF7L2 on the development and function of fat cells is still unclear. In a recent study, researchers from the University of Texas Health Science Center in the international academic journal Diabetes presented their latest advances in TCF7L2 in adipocyte development and function. The researchers first found in vitro that the expression of TCF7L2 protein was gradually increased during the differentiation of 3T3L1 and primary adipose precursor cells, and the expression of TCF7L2 was required for the regulation of Wnt signaling on adipogenesis. Subsequently, they removed the HMG-box DNA binding domain of TCF7L2 protein in mouse mature adipocytes, which was found to cause systemic glucose intolerance and hepatic insulin resistance in mice. This phenotype is also accompanied by an increase in the amount of subcutaneous fat, fat cell hypertrophy, and inflammation. Finally, the researchers observed that patients with impaired glucose tolerance and insulin resistance in adipocytes found that TCF7L2 mRNA expression was down-regulated in their adipocytes. These results suggest that TCF7L2 plays a key role in adipose tissue development and function, and this study partially reveals how TCF7L2 promotes the development of type 2 diabetes. Source: Bio Valley Injection Solution,Compound Vitamin B Injection,Astragalus Polysaccharide Injection,Sulfamonomethoxine Sodium Injection Sichuan Aibang Weiye Biological Engineering Co., Ltd. , https://www.aibangpharm.com