Researchers have developed a new "dopamine fluorescent probe" to help precision medicine July 27, 2018 Source: Xinhua Author: Wei Mengjia Xinhua News Agency, Beijing, July 26th, Chinese scientists recently published an important achievement online in the international authoritative academic journal Cell. The researchers developed a new, genetically encoded dopamine fluorescent probe. It is reported that the probe is expected to become an important tool for studying dopamine-related neural circuits, providing a new path for future precision medicine and new drug development. Dopamine is an important neurotransmitter in the brain that regulates a range of key neurological functions in the central nervous system, including learning, memory, attention, and motor control. Dopamine disorders can lead to mental illness or neurodegenerative diseases such as ADHD, schizophrenia and the like. Dopamine-related neural circuits are also targets for addictive drugs such as cocaine. To better investigate the role of dopamine in physiology and pathology, researchers need to detect changes in dopamine signaling in specific brain regions in vivo. However, traditional detection methods often fail to meet research needs due to lack of sufficient temporal and spatial resolution and difficulty in accurately reflecting the true dynamic information of neurotransmitters. To this end, the research team of the Peking University School of Life Sciences, Li Yulong, and a team of researchers have developed a genetically-encoded dopamine probe that inserts a fluorescent protein sensitive to structural changes into the dopamine receptor, converting the chemical signal of dopamine into fluorescence. Signals, combined with existing imaging techniques, allow real-time monitoring of dynamic changes in dopamine concentrations. "This is equivalent to having a good candle that can light up dopamine, which is often invisible and intangible, and see its dynamic changes through imaging." Li Xiaolong, a researcher at the School of Life Sciences at Peking University, said. It is reported that the research team optimized the probe to have extremely high molecular specificity and spatiotemporal resolution. In addition, two versions of the probe have been developed for use in brain regions with different levels of dopamine release. It is noteworthy that due to the gene-encoded nature of the probe, the researchers also expressed the probe in cells, mouse brain slices or living flies, zebrafish, mice by means of transfection, virus injection, etc. on. Using the probe, they detected dopamine release induced by electrical stimulation of mouse brain slices and detected dopamine associated with olfactory stimulation, visual stimulation, learning and memory, and mating behavior in the brains of living Drosophila, zebrafish, and mice. Signal changes. Li Xiaolong said that the development of new neurotransmitter probes will help to understand the changes in neurotransmitters in specific diseases, thus providing a new path for future precision medicine and new drug development. Industry experts believe that this study makes use of the natural neurotransmitter receptors combined with fluorescent proteins to develop a highly efficient probe that can directly convert neurotransmitter signals into fluorescent signals, providing a useful tool for industry research. Â Medical Bed
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