Why are some people more afraid of pain? November 06, 2018 Source: Science and Technology Daily When seeking medical advice, the most common symptom of the patient is pain. But people feel pain, endure pain, and respond differently to pain, making it difficult for doctors to know how to treat each patient effectively. So why is everyone's pain different? The US Fun Science website recently reported that all the pain we have experienced in our lives stems from genes that make us more or less sensitive to pain. However, our mental and physical state, past pain and traumatic experiences, and the environment all adjust our response. If you can better understand the circumstances, what makes individuals more sensitive or less sensitive to pain, it will be easier to develop personalized pain treatments to alleviate people's suffering. Moreover, this personalized treatment can reduce the risk of drug abuse, misuse and tolerance. Different people have different pain genes With human genome sequencing technology, we have a lot of knowledge about the number and location of genes that make up human DNA codes, and we have discovered millions of tiny variations in these genes. These variations come in many forms, but the most common are single nucleotide polymorphisms (SNPs), which represent a single difference in each unit that makes up the DNA. There are about 10 million known SNPs in the human genome: a human SNP combination constitutes its DNA code and is different from others. When a SNP is very common, it is called mutation; when a SNP is rare, that is, it exists only in less than 1% of the total population, it is called a mutation. There is growing evidence that dozens of genes and variants determine our pain sensitivity, the extent to which analgesics such as opioids reduce pain, and even the risk of chronic pain. In the 1960s, it was reported that the families of some people with strong resilience were genetically linked. There were no techniques to determine the cause of the disease at the time, but from these rare families we know that congenital pain insensitivity is due to specific mutations or deletions in the individual genes required to transmit pain signals. Most commonly, one of the few SNPs within the SCN9A gene, a gene encoding a protein pathway necessary for the transmission of pain signals. This situation is rare: in the United States, only a few cases are documented. It doesn't seem to be a blessing to feel pain, but these families must always be alert to serious injuries or deadly diseases. Normally, a child will cry after falling, but people with this disease will not feel pain and can not distinguish between the pain caused by knee abrasions and tibia fractures. Insensitivity to pain means that there is no chest pain that predicts a heart attack, or a right lower quadrant pain that is a sign of appendicitis. Therefore, fatal consequences may have occurred before the problem is detected. The SCN9A gene mutation not only causes people to be insensitive to pain, but also causes two serious diseases characterized by extreme pain: primary erythema and paroxysmal extreme pain. In these cases, mutations in the SCN9A gene cause more pain signals than normal, but these types of hereditary pain conditions are rare. However, as the public is increasingly receiving genomic medicine and demanding more precise personalized healthcare strategies, researchers are turning these findings into personalized pain treatments that match the patient's genes. Genetic variation affects pain differences We know that scientists have been trying to "pull out" the main genes and new genes that affect pain perception. The SCN9A gene is a major player in controlling the body's response to pain by activating or silencing the sodium channel, but whether it amplifies or reduces pain depends on the mutations carried by the individual. According to scientists, up to 60% of pain differences are the result of genetic factors, which means that pain sensitivity is transmitted through the family through normal genetic inheritance, just like height, hair color or skin color. It turns out that SCN9A also plays an important role in the pain of the normal population. The relatively more common SNP "3312G>T" in SCN9A, which occurs in 5% of the population, determines the patient's postoperative sensitivity to pain and how many opioids are needed to control the pain. Another SNP in the SCN9A gene is more sensitive to pain caused by osteoarthritis, lumbar disc removal surgery, amputation limbs, and pancreatitis. Need better pain relief In terms of treatment, we have been using local anesthetics (including lidocaine, etc.) to treat pain by short-term blockage of the induced channels to prevent pain transmission. For more than a century, these drugs have been used to safely and effectively stop pain. But now, scientists have decided to find another way to find other pain relief methods. Interestingly, researchers are evaluating tetrodotoxin. This is a potent neurotoxin produced by marine organisms such as puffer fish and octopus. It acts as a potential painkiller by preventing the spread of pain signals. These toxins have been shown to treat early onset of cancer pain and migraine. We have now realized that in addition to opioids, we need more precise tools for treating pain, treating pain from the source and reducing side effects and risks. By understanding the genetics of pain sensitivity and susceptibility to chronic pain and even analgesic responses, we can design better therapies to better address the “why pain†problem? Only when we learn more about the difference in pain from person to person will humanity benefit greatly. pain relief device, physiotherapy equipment, Other household physical therapy device Shenzhen Guangyang Zhongkang Technology Co., Ltd. , https://www.szlighttherapymachine.com