Process technology Application examples Ion exchange resin separation Synephrine, Huperzine A Macroporous adsorption resin separation Ginkgo biloba extract, soy isoflavones Continuous countercurrent extraction Green tea extract, red clover extract High-speed countercurrent distribution chromatography Tea EGCG (trial production) Adsorption chromatography Paclitaxel, ginkgolide Supercritical extraction Aromatic oils, natural vitamin E Freeze drying Garlic extract Hormone inclusion Angelica extract (including volatile oil) Enzymatic hydrolysis Resveratrol Lab Nitrile Gloves,Disposable Gloves,510K Disposable Gloves,Astm D6319 Examination Gloves Puyang Linshi Medical Supplies Co., Ltd. , https://www.linshihealths.com
Industrial extraction technology. Including: 1 organic solvent extraction technology; 2 carbon dioxide supercritical fluid extraction technology, which was introduced in the 1990s, is the use of liquid CO2 under high pressure (350-500 bar) to extract plant active ingredients, the resulting product is high purity, high yield, The extractant is non-polluting. However, due to the high working pressure, the equipment requirements are high, and currently only the pilot level; 3 new chlorofluorocarbon solvent extraction, such as the British "Klea" (HFC134α, 1,1,1,2 tetrafluorohexane) An inert solvent that can be extracted at low pressure room temperature to save energy and avoid thermal damage.
Ultrasonic extraction and separation technology: Ultrasonic Chinese medicine extraction tank is mainly used in traditional Chinese medicine, food, agricultural products, health care products and other industries. It is widely used in the extraction of active ingredients from traditional Chinese medicine and natural plants. It is suitable for various solvents (water or ethanol, petroleum ether, acetone, etc.). Solvent); is the new construction, renovation and expansion of the extraction workshop; new drugs, new product development; medical science institutes, university pharmaceutical companies and enterprises engaged in extraction using various methods to extract traditional Chinese medicines and natural products from botanicals and animal herbs, experimental research, etc. The ideal extraction equipment for the application; the whole machine is small in size, beautiful in appearance, easy to clean and maintain, and meets GMP certification requirements. Ultrasonic extraction technology mainly uses the fast mechanical vibration wave generated by the piezoelectric transducer to reduce the force between the target extract and the sample matrix to achieve solid-liquid extraction separation. According to this principle and its working characteristics, the medicinal substances in Chinese medicinal materials can be processed efficiently. The application of this technology has an important position in the field of traditional Chinese medicine. Humans have also brought about the development of this ultrasonic extraction Chinese medicine technology in progress, and have also applied more widely to the treatment of Chinese herbal medicines. Therefore, this technology has also appeared in its development. There are many ways to effectively treat Chinese herbal medicines. The economic benefits brought about by social progress cannot be ignored. Jining Hengshuo Ultrasonic Machinery Co., Ltd. has been engaged in ultrasonic extraction technology for several years, and finally achieved a little achievement in ultrasonic extraction. Welcome friends from all over the country to discuss and discuss ultrasonic extraction technology, so that China's ultrasonic extraction technology can achieve greater development!
Table 1-2-1: Application examples of advanced technology in the production of plant extracts Source: State Drug Administration
Analytical detection technology: Chinese herbal extracts require quantitative analysis of the target components and harmful substances, or with the standard products, or with fingerprints for identification, raw materials, production processes and finished products are strictly tested to the US natural sunlight For example, the company started a total of 150 tests from raw materials to finished products. Therefore, in the quality control of traditional Chinese medicine extracts, modern analytical instruments are indispensable, and HPLC applications are widely used, as well as methods and instruments such as GC, HPCE, GC-MS, HPLC-MS, UV and atomic spectroscopy. Often used. According to statistics, about 75% of the Chinese herbal medicine extracts were tested by HPLC, while only 10.9% of the Chinese patent medicines contained in the Chinese Pharmacopoeia were used. Companies with lower levels of technology often do not have the ability to analyze instruments, and commercial enterprises rarely have these conditions.
The main industrial separation technology of modern botanicals
Resin separation technology. Resin technology has been successfully applied in industrial decolorization, environmental protection, drug analysis, antibiotic extraction and separation. Separation and concentration of phytochemical components have also been extremely successful. For example, for ginkgo biloba, the current resin separation technology can achieve a collection rate of 90% of ginkgo flavonoids; it can concentrate gingko flavonoids at one time to make it more than 50%; it can also remove most (more than 99.5%) as The harmful component of ginkgolic acid is made lower than 5 ppm while the active ingredient loss is controlled below 3%.