Best Price/High Quality Trilostane CAS 13647-35-3

October 31, 2018

Model NO.: 13647-35-3
Appearance: White Crystals
Sample: Free
Transport Package: 1kg/Aluminum Bags
Specification: Density: 1.1 g/cm3
Origin: China
HS Code: 0101102458
Model NO.: 13647-35-3
Appearance: White Crystals
Sample: Free
Transport Package: 1kg/Aluminum Bags
Specification: Density: 1.1 g/cm3
Origin: China
HS Code: 0101102458
Active Pharmaceutical Ingredients Trilostane CAS 13647-35-3 for Breast Cancer
 
 
Quick Details of Active Pharmaceutical Ingredients Trilostane 
 
Product Name: Trilostane
Synonyms: TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal;
 
CAS: 13647-35-3;
MF: C20H27NO3;
EINECS: 237-133-0;
MW: 329.43.
 
Product name: Trilostane
Other Name: TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal;
 
Original: China
CAS: 13647-35-3
Molecular formula: C20H27NO3
MW: 329.43.
EINECS: 237-133-0
Brand name NJBNSteroid
Leading time within 24 hours upon receipt of payment
Delivery Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity 99%
Package Discreet and Hidden package according to specific requirement
Appearance White Powder
Certification SGS, ISO 9001, KOSHER
Payment Terms Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity 10g
Price Negotiable
Usage An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer
Molecular structure  
 
 
Overview of Active Pharmaceutical Ingredients Trilostane
 
1. Trilostane is an inhibitor of 3beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome and primary hyperaldosteronism. These are both disorders where excess amounts of corticosteroid hormones are produced in the body.
 
2. Corticosteroids are essential for the body to make use of carbohydrates, fats and proteins and for a normal response to stress. They are also necessary for the regulation of salt and water balance in the body. Trilostane helps prevent the production of corticosteroids, controlling the symptoms associated with these disorders.
3. Trilostane can also be useful in the treatment of breast cancer that has relapsed in women who have gone through menopause.
 
Technical Test Sheet of Active Pharmaceutical Ingredients Trilostane
 
Items Specification Results
Appearance white oralmost white,crystalline powder Conform
Solubility Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. Conform

Identification		 A The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64.
Conform
B Infraed absorption spectrophotometry. Conform
C Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution.
Conform
D An orange-red color develop in methylene chloride layer. Conform
E It geves reaction (a) of sulphates. Conform
Appearance
of solution		 Solution S is clear and not more intensely coloured than reference solution in BY6. Conform
Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01°
Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. Conform

Related substances		 Impurity J ≤0.20% Conform
Any other impurity ≤0.30% Conform
Total impurity ≤1.0% Conform
Boron ≤50ppm Conform
Sulphated ash ≤0.10% 0.06%
Loss on drying ≤0.5% 0.30%
Assay(on dried basis) 98.0~101.0% 99.5%
Conclusion The test results above BP2009
 
Medical Application of Active Pharmaceutical Ingredients Trilostane
 
1. Uses in dogs:
 
Trilostane was withdrawn from the United States market in April 1994. However, it was approved in 2008 for the treatment of Cushing's disease (hyperandrenocorticism) in dogs.
It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs.

(1). has kidney or liver disease.
(2). takes certain medications used to treat heart disease.
(3). pregnant.
(4). taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
(5). had an allergic reaction to this or any other medicine. Active Pharmaceutical Ingredients Trilostane CAS 13647-35-3 for Breast Cancer
 
 
Quick Details of Active Pharmaceutical Ingredients Trilostane 
 
Product Name: Trilostane
Synonyms: TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal;
 
CAS: 13647-35-3;
MF: C20H27NO3;
EINECS: 237-133-0;
MW: 329.43.
 
Product name: Trilostane
Other Name: TRILOSTANE;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al;modrenal;
 
Original: China
CAS: 13647-35-3
Molecular formula: C20H27NO3
MW: 329.43.
EINECS: 237-133-0
Brand name NJBNSteroid
Leading time within 24 hours upon receipt of payment
Delivery Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity 99%
Package Discreet and Hidden package according to specific requirement
Appearance White Powder
Certification SGS, ISO 9001, KOSHER
Payment Terms Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity 10g
Price Negotiable
Usage An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer
Molecular structure  
 
 
Overview of Active Pharmaceutical Ingredients Trilostane
 
1. Trilostane is an inhibitor of 3beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome and primary hyperaldosteronism. These are both disorders where excess amounts of corticosteroid hormones are produced in the body.
 
2. Corticosteroids are essential for the body to make use of carbohydrates, fats and proteins and for a normal response to stress. They are also necessary for the regulation of salt and water balance in the body. Trilostane helps prevent the production of corticosteroids, controlling the symptoms associated with these disorders.
3. Trilostane can also be useful in the treatment of breast cancer that has relapsed in women who have gone through menopause.
 
Technical Test Sheet of Active Pharmaceutical Ingredients Trilostane
 
Items Specification Results
Appearance white oralmost white,crystalline powder Conform
Solubility Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. Conform

Identification		 A The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64.
Conform
B Infraed absorption spectrophotometry. Conform
C Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution.
Conform
D An orange-red color develop in methylene chloride layer. Conform
E It geves reaction (a) of sulphates. Conform
Appearance
of solution		 Solution S is clear and not more intensely coloured than reference solution in BY6. Conform
Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01°
Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. Conform

Related substances		 Impurity J ≤0.20% Conform
Any other impurity ≤0.30% Conform
Total impurity ≤1.0% Conform
Boron ≤50ppm Conform
Sulphated ash ≤0.10% 0.06%
Loss on drying ≤0.5% 0.30%
Assay(on dried basis) 98.0~101.0% 99.5%
Conclusion The test results above BP2009
 
Medical Application of Active Pharmaceutical Ingredients Trilostane
 
1. Uses in dogs:
 
Trilostane was withdrawn from the United States market in April 1994. However, it was approved in 2008 for the treatment of Cushing's disease (hyperandrenocorticism) in dogs.
It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs.

(1). has kidney or liver disease.
(2). takes certain medications used to treat heart disease.
(3). pregnant.
(4). taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
(5). had an allergic reaction to this or any other medicine.

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