99% Purity Raw Powder Nintedanib Effects on Ipf

November 02, 2018

Model NO.: 656247-17-5
Quality Standard: Bp, USP, Ep, Cp
Usage: Enhancement
Appearence: White or off-White Crystalline Power
Payment Method: T/T, Western Union, Money Gram, Paypal
Delivery Time: Shipped in 3 Days After Payment
Trademark: Shinrezing
Transport Package: Foil Bag, Drum or Carton
Origin: Hubei
Model NO.: 656247-17-5
Quality Standard: Bp, USP, Ep, Cp
Usage: Enhancement
Appearence: White or off-White Crystalline Power
Payment Method: T/T, Western Union, Money Gram, Paypal
Delivery Time: Shipped in 3 Days After Payment
Trademark: Shinrezing
Transport Package: Foil Bag, Drum or Carton
Origin: Hubei

Product Description

99% purity raw powder Nintedanib effects on IPF

Trade name: VARGATEF; OFEV
Alias: BIBF 1120;
CAS number: 656247-17-5
Molecular Formula: C31H33N5O4
Molecular weight: 539.62500
PSA: 94.22000
LogP: 3.70270
Physicochemical properties
Density: 1.284g/cm3
Boiling point: 742.199oC at 760 mmHg
Flash point: 402.667oC

Nintedanib is a small molecule tyrosine kinase inhibitor with anti-fibrotic and anti-inflammatory activity. Nintedanib inhibits multiple receptor tyrosine kinases (RTKs): platelet-derived growth factor receptor alpha and beta (PDGFR alpha, beta), fibroblast growth factor receptor 1-3 (FGFR1-3), and blood vessels Endothelial growth factor receptor 1-3 (VEGFR1-3) and Fms-like tyrosine kinase-3 (FLT3), where FGFR, PDGFR, and VEGFR are involved in the pathogenesis of IPF, and Nyinnib can compete for binding to these cells. The adenosine triphosphate (ATP) binding site on the inner receptor kinase domain blocks intracellular signaling and inhibits proliferation, migration, and transformation of fibroblasts. In addition, nidanib also inhibits the following non-receptor tyrosine kinases (nRTK): Lck, Lyn, and Src kinases. It is not clear that it inhibits the effect of FLT3 and nRTK on the efficacy of IPF.

Toxicological research
Genotoxicity
Nintedanib Ames test, in vitro mouse lymphoma cell test, in vivo rat micronucleus test results were negative.
Reproductive toxicity
Oral administration of Nintedanib 100 mg/kg/day in rats (rat exposure in vivo to approximately 3 times the AUC of adult maximum recommended dose MRHD) can cause female reproductive dysfunction, showing increased numbers of lost fetuses after embryo implantation and embryo implantation , Decrease in pregnancy index; no adverse effects on the male reproductive system and fertility. Repeated oral administration of Nintedanib to rats and mice revealed changes in the number and size of corpus luteum in the female ovary. Embryo reabsorption was seen only at a dose of 20 mg/kg/day (exposure equivalent to 1x the AUC at the MRHD dose). The number of females increased.
In an embryonic-fetal developmental toxicity test, pregnant rats and rabbits were orally administered with Nintedanib 2.5 mg/kg/day and 15 mg/kg/day, respectively (exposures were In a two-year carcinogenicity test, mice and rats were orally administered with Nintedanib at 10 mg/kg/day and 30 mg/kg/day, respectively (exposures were defined as auc at the dose of mrhd and the equivalent of auc at the mrhd dose. 4 times) no carcinogenicity.

 

COA:
 

Product name
Nintedanib (BIBF 1120)

CAS No.
656247-17-5
Outer Packing
100G/ foil bag

Production date
2018.06.04
Shelf life
2020.06.03

Standard adopted
Enterprise Standard

Items of analysis
Specification
Results

Appearance
Yellow powder
Complies

Identification
HPLC
Complies

Assay (HPLC)		 >99.0%  99.8%

Related substance		 <1.0%  0.2%

Single impurity
<0.2% 
0.06%

Loss on drying
<1.0%
0.20%

Ignition residue
<0.2%
0.06%

Conclusion
Qualified


 

Steroids Injection  List

Abbreviation Active ingredients
mg/ml 		Specifications
ml/Vial
SU-250 Test-Pr30mg
Test-pp 60mg
Test-I60mg
Test-D 100mg		 10ml
SU-400 Tes-P 48mg
Test-pp 96mg
Test-I 96mg
Test-D 160mg		 10ml
Test-mix-325 Tes-P 65mg
Test-pp 65mg
Test-Cy 85mg
Test-D110mg		 10ml
TE-300 Test-E 300mg 10ml
TE-250 Test-E 250mg 10ml
TC-200 Test-Cy 200mg 10ml
TP-100 Test-Pr 100mg 10ml
N-PP-200 Nan-dro-PP 200mg 10ml
N-PP-100 Nan-dro-PP 100mg 10ml
DECA-300(ND-300) Nan-dro-De 300mg 10ml
ND-mix-300 Nan-dro-PP 100mg
Nan-dro-DE 200mg		 10ml
BO-LDEN-300 Bold-U 300mg 10ml
BO-LDEN-600 Bold-U 600mg 10ml
TR-EN-A75 Tr-en-A 75mg 10ml
TR-EN-100 Tr-en-En 100mg 10ml
TR-EN-mix-200 Tr-en-A 75mg
Tr-en-En 125mg		 10ml
DP-100 Dro-stan-Pr 100mg 10ml
DP-150 Dro-stan-Pr 150mg 10ml
MAST-200 Dro-stan-Pr 50mg
Dro-stan-En 150mg		 10ml
TrX-100 Tr-en-En 50mg
Tr-en-Hex 50mg		 10ml
PRIMO-100 Me-then-En 100mg 10ml
PR-OVI-100 Me-ster/pr-ovir 100mg 10ml
Blend-500 Tr-en-E 250mg  Ma-st-E 250mg 10ml
Blend-375 Tr-en-E 125mg  Ma-st E 125mg
Test-E 125		 10ml
No-lvadex-20 No-lvadex 20mg 10ml
An-avar-20 An-avar 20mg 10ml
An-adrol-50 An-adrol-50 10ml
Dian-abol-50 Me-than/ Di-anabol 50mg 10ml
Win-stro-50 Stan-oz/win-str50mg 10ml
Win-stro-100 Stan-oz/win-strol 100mg 10ml
TU-300 Test-U 300mg 10ml

Other products:


Anti-cancer & Antineoplastic Products
CAS No.

Ceritinib Intermediate		 1802250-63-0

Gefitinib/ ZD1839/ Iressa		 184475-35-2

Floxuridine		 50-91-1

Pazopanib		 444731-52-6

Pazopanib HCl		 635702-64-6

Gemcitabine		 95058-81-4

Gemcitabine Hydrochloride		 122111-03-9

Cabozantinib/ Cabometyx/ XL184/ BMS907351		 849217-68-1

Palbociclib		 571190-30-2

Xalkori/ Crizotinib		 877399-52-5

Lapatinib/ Tyverb		 231277-92-2

Bismaleate Afatinib		 850140-73-7

Regorafenib/ BAY 73-4506/ Stivarga		 755037-03-7

Vemurafenib/ Zelboraf		 918504-65-1

Vandetanib/ Zactima		 443913-73-3

Aminoglutethimide/ Cytadren		 125-84-8

Methotrexate/ Trexall/ Rheumatrex		 59-05-2

Lomustine 98%		 13010-47-4

Lomustine 99%		 13010-47-4

Selumetinib		 606143-52-6

Olaparib/ AZD-2281/ Lynparza		 763113-22-0

Mitoxantrone HCl		 70476-82-3

Dabrafenib/ Tafinlar		 1195765-45-7

Anamorelin		 249921-19-5

Osimertinib Mesylate/ AZD9291		 1421373-66-1

AP26113/ Alunbrig		 1197958-12-5

Sorafenib Tosylate		 475207-59-1

 


How to order quickly and safely? 

Step 1 (Inquiry) Please let me know the items you are favorable, quantities, and the destination country. 
Step 2 (Offer) We offer you price and the suitable shipping method for your reference. 
Step 3 (Negotiation) We will negotiate price, terms of payment, transport, delivery time, arrival time, destination of the goods and after-sales service. 
Step 4 (Order) After receiving your order, we will check it and get prepared for it. 
Step 5 (Payment) Please confirm the order and pay money 100% in advance, then send us the detailed contacting information, including contacting person/company, address, mobile number, ZIP code and your special requirements. 
Step 6 (Package & Delivery) Parcel will be arranged within 24 hours upon receipt of your payment. And photos will be offered to tell apart the products. 
Step 7 (Tracking number) If sent by EMS, the tracking number is availabe within 12 hours. The info will be trackable that day or next day. 
If sent by HKEMS or other express, the tracking number will be provided next day. And this does not mean the info is trackable that day. It will be released on internet 2 or 3 days later, because the parcel has to be shipped to Hongkong fist, and then wait for the flight. 
Step 8 (After-Sales Service) Within the terms of the contract, If there is any problem about the goods quality, quantity and other problems, we will assure you to make you satisfied with the results.  



 



99% Purity Raw Powder Nintedanib Effects on Ipf




 
Packaging









99% Purity Raw Powder Nintedanib Effects on Ipf











Shipping Method









99% Purity Raw Powder Nintedanib Effects on Ipf












 
Company Information
Hubei Shinrezing Pharmaceutical Technology Co.,Ltd.(hereafter shorted as Shinrezing) is located in Wuhan Donghu High-Tech Economic Development Zone and established in 2008 with registered capital is RMB 10 million yuan (about USD 1.5 million ). Its manufacturing base is located in Dawu Industrial Park in Dawu County, Xiaogan City, Hubei Province which is built in 2010 with 25,000 square meters covered area.
 
Shinrezing is a rapid growing enterprise, which integrates the production, R&D, sales and trading of APIs, steroid raw materials, pharmaceutical intermediates, plant extracts, other kinds of organic intermediates etc. Shinrezing is not only a manufacturing company but also a trade company, it also has very good cooperation relationships with some manufacturers qualified with GMP, DMF to meet the different customers' needs from grams to tonnage quantity, which makes Shinrezing to be more flexible and easily to supply highly cost-effective products with high quality and better service to customers.
Shinrezing always stands in high starting, high stand and high quality, and masters strict management for production procedure and quality control. All the products must pass our quality test before being sending to customers. Shinrezing's products have been exported to more than 50 countries and regions all over the world, including United States, Europe, Japan, Korea, Russia, Hong kong, Taiwan and so on, and enjoy a good reputation from domestic and oversea customers
 
Shinrezing's mission is: "Innovative and Pragmatic, Mutual Benefits, Serve the World". Every staff member will keep this in mind all the time, and enforce it at every detail of operation and management of the company. We are always trying our best to offer the best services and the most competitive prices with high quality goods for our customers. All honors belong to the past, Shinrezing people will do their best to develop and produce more perfect product and contribute to the chemical pharmaceutical industries worldwide.

We are confident that Shinrezing will be your best solution.

99% Purity Raw Powder Nintedanib Effects on Ipf
99% Purity Raw Powder Nintedanib Effects on Ipf


 
FAQ
Order Guide
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Paypal or  Moneygram

Q6:How long does it take to the goods arrived ?
It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.
 
We have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .
please donot hesitate to contact us.
 

Product Description

99% purity raw powder Nintedanib effects on IPF

Trade name: VARGATEF; OFEV
Alias: BIBF 1120;
CAS number: 656247-17-5
Molecular Formula: C31H33N5O4
Molecular weight: 539.62500
PSA: 94.22000
LogP: 3.70270
Physicochemical properties
Density: 1.284g/cm3
Boiling point: 742.199oC at 760 mmHg
Flash point: 402.667oC

Nintedanib is a small molecule tyrosine kinase inhibitor with anti-fibrotic and anti-inflammatory activity. Nintedanib inhibits multiple receptor tyrosine kinases (RTKs): platelet-derived growth factor receptor alpha and beta (PDGFR alpha, beta), fibroblast growth factor receptor 1-3 (FGFR1-3), and blood vessels Endothelial growth factor receptor 1-3 (VEGFR1-3) and Fms-like tyrosine kinase-3 (FLT3), where FGFR, PDGFR, and VEGFR are involved in the pathogenesis of IPF, and Nyinnib can compete for binding to these cells. The adenosine triphosphate (ATP) binding site on the inner receptor kinase domain blocks intracellular signaling and inhibits proliferation, migration, and transformation of fibroblasts. In addition, nidanib also inhibits the following non-receptor tyrosine kinases (nRTK): Lck, Lyn, and Src kinases. It is not clear that it inhibits the effect of FLT3 and nRTK on the efficacy of IPF.

Toxicological research
Genotoxicity
Nintedanib Ames test, in vitro mouse lymphoma cell test, in vivo rat micronucleus test results were negative.
Reproductive toxicity
Oral administration of Nintedanib 100 mg/kg/day in rats (rat exposure in vivo to approximately 3 times the AUC of adult maximum recommended dose MRHD) can cause female reproductive dysfunction, showing increased numbers of lost fetuses after embryo implantation and embryo implantation , Decrease in pregnancy index; no adverse effects on the male reproductive system and fertility. Repeated oral administration of Nintedanib to rats and mice revealed changes in the number and size of corpus luteum in the female ovary. Embryo reabsorption was seen only at a dose of 20 mg/kg/day (exposure equivalent to 1x the AUC at the MRHD dose). The number of females increased.
In an embryonic-fetal developmental toxicity test, pregnant rats and rabbits were orally administered with Nintedanib 2.5 mg/kg/day and 15 mg/kg/day, respectively (exposures were In a two-year carcinogenicity test, mice and rats were orally administered with Nintedanib at 10 mg/kg/day and 30 mg/kg/day, respectively (exposures were defined as auc at the dose of mrhd and the equivalent of auc at the mrhd dose. 4 times) no carcinogenicity.

 

COA:
 

Product name
Nintedanib (BIBF 1120)

CAS No.
656247-17-5
Outer Packing
100G/ foil bag

Production date
2018.06.04
Shelf life
2020.06.03

Standard adopted
Enterprise Standard

Items of analysis
Specification
Results

Appearance
Yellow powder
Complies

Identification
HPLC
Complies

Assay (HPLC)		 >99.0%  99.8%

Related substance		 <1.0%  0.2%

Single impurity
<0.2% 
0.06%

Loss on drying
<1.0%
0.20%

Ignition residue
<0.2%
0.06%

Conclusion
Qualified


 

Steroids Injection  List

Abbreviation Active ingredients
mg/ml 		Specifications
ml/Vial
SU-250 Test-Pr30mg
Test-pp 60mg
Test-I60mg
Test-D 100mg		 10ml
SU-400 Tes-P 48mg
Test-pp 96mg
Test-I 96mg
Test-D 160mg		 10ml
Test-mix-325 Tes-P 65mg
Test-pp 65mg
Test-Cy 85mg
Test-D110mg		 10ml
TE-300 Test-E 300mg 10ml
TE-250 Test-E 250mg 10ml
TC-200 Test-Cy 200mg 10ml
TP-100 Test-Pr 100mg 10ml
N-PP-200 Nan-dro-PP 200mg 10ml
N-PP-100 Nan-dro-PP 100mg 10ml
DECA-300(ND-300) Nan-dro-De 300mg 10ml
ND-mix-300 Nan-dro-PP 100mg
Nan-dro-DE 200mg		 10ml
BO-LDEN-300 Bold-U 300mg 10ml
BO-LDEN-600 Bold-U 600mg 10ml
TR-EN-A75 Tr-en-A 75mg 10ml
TR-EN-100 Tr-en-En 100mg 10ml
TR-EN-mix-200 Tr-en-A 75mg
Tr-en-En 125mg		 10ml
DP-100 Dro-stan-Pr 100mg 10ml
DP-150 Dro-stan-Pr 150mg 10ml
MAST-200 Dro-stan-Pr 50mg
Dro-stan-En 150mg		 10ml
TrX-100 Tr-en-En 50mg
Tr-en-Hex 50mg		 10ml
PRIMO-100 Me-then-En 100mg 10ml
PR-OVI-100 Me-ster/pr-ovir 100mg 10ml
Blend-500 Tr-en-E 250mg  Ma-st-E 250mg 10ml
Blend-375 Tr-en-E 125mg  Ma-st E 125mg
Test-E 125		 10ml
No-lvadex-20 No-lvadex 20mg 10ml
An-avar-20 An-avar 20mg 10ml
An-adrol-50 An-adrol-50 10ml
Dian-abol-50 Me-than/ Di-anabol 50mg 10ml
Win-stro-50 Stan-oz/win-str50mg 10ml
Win-stro-100 Stan-oz/win-strol 100mg 10ml
TU-300 Test-U 300mg 10ml

Other products:


Anti-cancer & Antineoplastic Products
CAS No.

Ceritinib Intermediate		 1802250-63-0

Gefitinib/ ZD1839/ Iressa		 184475-35-2

Floxuridine		 50-91-1

Pazopanib		 444731-52-6

Pazopanib HCl		 635702-64-6

Gemcitabine		 95058-81-4

Gemcitabine Hydrochloride		 122111-03-9

Cabozantinib/ Cabometyx/ XL184/ BMS907351		 849217-68-1

Palbociclib		 571190-30-2

Xalkori/ Crizotinib		 877399-52-5

Lapatinib/ Tyverb		 231277-92-2

Bismaleate Afatinib		 850140-73-7

Regorafenib/ BAY 73-4506/ Stivarga		 755037-03-7

Vemurafenib/ Zelboraf		 918504-65-1

Vandetanib/ Zactima		 443913-73-3

Aminoglutethimide/ Cytadren		 125-84-8

Methotrexate/ Trexall/ Rheumatrex		 59-05-2

Lomustine 98%		 13010-47-4

Lomustine 99%		 13010-47-4

Selumetinib		 606143-52-6

Olaparib/ AZD-2281/ Lynparza		 763113-22-0

Mitoxantrone HCl		 70476-82-3

Dabrafenib/ Tafinlar		 1195765-45-7

Anamorelin		 249921-19-5

Osimertinib Mesylate/ AZD9291		 1421373-66-1

AP26113/ Alunbrig		 1197958-12-5

Sorafenib Tosylate		 475207-59-1

 


How to order quickly and safely? 

Step 1 (Inquiry) Please let me know the items you are favorable, quantities, and the destination country. 
Step 2 (Offer) We offer you price and the suitable shipping method for your reference. 
Step 3 (Negotiation) We will negotiate price, terms of payment, transport, delivery time, arrival time, destination of the goods and after-sales service. 
Step 4 (Order) After receiving your order, we will check it and get prepared for it. 
Step 5 (Payment) Please confirm the order and pay money 100% in advance, then send us the detailed contacting information, including contacting person/company, address, mobile number, ZIP code and your special requirements. 
Step 6 (Package & Delivery) Parcel will be arranged within 24 hours upon receipt of your payment. And photos will be offered to tell apart the products. 
Step 7 (Tracking number) If sent by EMS, the tracking number is availabe within 12 hours. The info will be trackable that day or next day. 
If sent by HKEMS or other express, the tracking number will be provided next day. And this does not mean the info is trackable that day. It will be released on internet 2 or 3 days later, because the parcel has to be shipped to Hongkong fist, and then wait for the flight. 
Step 8 (After-Sales Service) Within the terms of the contract, If there is any problem about the goods quality, quantity and other problems, we will assure you to make you satisfied with the results.  



 



99% Purity Raw Powder Nintedanib Effects on Ipf




 
Packaging









99% Purity Raw Powder Nintedanib Effects on Ipf











Shipping Method









99% Purity Raw Powder Nintedanib Effects on Ipf












 
Company Information
Hubei Shinrezing Pharmaceutical Technology Co.,Ltd.(hereafter shorted as Shinrezing) is located in Wuhan Donghu High-Tech Economic Development Zone and established in 2008 with registered capital is RMB 10 million yuan (about USD 1.5 million ). Its manufacturing base is located in Dawu Industrial Park in Dawu County, Xiaogan City, Hubei Province which is built in 2010 with 25,000 square meters covered area.
 
Shinrezing is a rapid growing enterprise, which integrates the production, R&D, sales and trading of APIs, steroid raw materials, pharmaceutical intermediates, plant extracts, other kinds of organic intermediates etc. Shinrezing is not only a manufacturing company but also a trade company, it also has very good cooperation relationships with some manufacturers qualified with GMP, DMF to meet the different customers' needs from grams to tonnage quantity, which makes Shinrezing to be more flexible and easily to supply highly cost-effective products with high quality and better service to customers.
Shinrezing always stands in high starting, high stand and high quality, and masters strict management for production procedure and quality control. All the products must pass our quality test before being sending to customers. Shinrezing's products have been exported to more than 50 countries and regions all over the world, including United States, Europe, Japan, Korea, Russia, Hong kong, Taiwan and so on, and enjoy a good reputation from domestic and oversea customers
 
Shinrezing's mission is: "Innovative and Pragmatic, Mutual Benefits, Serve the World". Every staff member will keep this in mind all the time, and enforce it at every detail of operation and management of the company. We are always trying our best to offer the best services and the most competitive prices with high quality goods for our customers. All honors belong to the past, Shinrezing people will do their best to develop and produce more perfect product and contribute to the chemical pharmaceutical industries worldwide.

We are confident that Shinrezing will be your best solution.

99% Purity Raw Powder Nintedanib Effects on Ipf
99% Purity Raw Powder Nintedanib Effects on Ipf


 
FAQ
Order Guide
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Paypal or  Moneygram

Q6:How long does it take to the goods arrived ?
It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.
 
We have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .
please donot hesitate to contact us.
 

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