Introduction of wet mixing granulator technology

The wet mixing granulator is a relatively fast solid pharmaceutical preparation equipment developed in recent years. The process combines the two-step mixing and granulation process, which saves time and meets GMP requirements and reduces cross-contamination. Improving efficiency is a quick and easy way to save and is very popular among users. In the current solid preparation process, the wet mixing granulator is a granulation device which is used more, and is also economical. According to incomplete statistics in the pharmaceutical industry, it accounts for 70% of all solid preparation granulation equipment.

Due to the use of the wet mixing granulator and the tablet press, the annual sales volume of the wet mixing granulator has a high market share. Wet mixing granulators have been widely used in foreign countries. They have only emerged in China in recent years, and some users have chosen pharmaceutical equipment that is not a professional manufacturer. Therefore, when debugging on site, because they do not understand the preparation process, they do not understand. Using skills, the results have repeatedly failed, and suffered. For the development of solid preparations in China, to help users to use the wet mixing equipment purchased, we hereby publish this article for your reference.

Generally speaking, the particles prepared by wet mixing granulation have irregular shape, uniform particle size distribution, better structure than other conventional granulation processes, strong compressibility, good solubility and moderate moisture permeability. At different granulating speeds, the particle size of the particles is between 12 and 100 mesh. The distribution range can be selected from different granulation speeds and stirring paddle speeds. (When the granulation speed is slow, the particle size becomes larger and the rotation speed is gradually increased. Accelerate and gradually reduce the particle size; when the stirring paddle speed is slow, the particle size is small, the rotation speed is gradually increased and the particle size is gradually increased, and the two functions are just the opposite).

Conventional wet mixing granulators can be used to manually adjust the speed of the paddles and granulation paddles in order to find out the experimental process parameters. That is to say, the two blade speeds are changed through different time, and the better particle size parameters are obtained. According to the two inverters, the program control is performed to ensure the quality and uniformity of batch and batch production.