Recently, the "Academic Academy of the United States Academy of Sciences" published the latest research results of the team of Su Youqiang, National Key Laboratory of Reproductive Medicine, Nanjing Medical University. The study found that the dialogue between the egg and follicular cells mediated by the MTOR signal in vivo has a decisive effect on granule cell fate and egg quality. In layman's terms, whether women can excrete healthy eggs, the MTOR gene in the body plays a decisive role. The gene is a key factor in the coding of nutrient and stress-sensing signaling pathways, and female infertility may be the disorder of the gene. According to reports, egg quality decline, premature ovarian failure and insufficient estrogen levels are the culprit of diseases such as female infertility and endocrine disorders. Many women suffering from infertility are affected by nutrient metabolism and stress, in addition to genetic factors. The impact of factors. And what is the cause of it, has always made people who suffer from it unclear. Through the mouse experiment, Su Youqiang's team found that the MTOR signaling pathway is "like the shape" in the developmental stages of female follicles, but the mechanism of action is completely different at different times. Oocytes at the earliest developmental stage are not in a "dormant" state as previously reported; instead, oocytes during this period have active response through the MTOR pathway. This period is equivalent to the puberty of human females. By knocking out the animal model of the MTOR pathway, the research team found that once the MTOR pathway is missing, the female animal will not be able to discharge healthy eggs, that is, not pregnant. Through intervention experiments in the development of follicles, the researchers found that the MTOR deletion in the oocyte oocytes of the growing period did not present these abnormalities, but only caused the meiosis defects of the eggs, as well as the fertilization of the eggs and the potential for early embryo development. The study also found that the absence of the MTOR pathway does not affect the activation of oocytes in the primordial follicle pool, but it is not possible to expel normal healthy eggs. This is different from what was speculated in the previous literature. Researcher Dr. Zhang Teng said that maintaining the pathway in optimal activity is the key to maintaining normal ovarian function and healthy pregnancy in women. The researchers pointed out that mutation detection of the MTOR gene itself may not be necessary because it is too important, and lack of function will not produce surviving individuals. However, the downstream genes found in the study and which play a decisive role in egg mass and granule cell fate can be used as potential targets for pre-pregnancy screening in women for clinical research. (Reporter Cheng Shouqin correspondent Zhang Yanhui) Cooking Wine 3Yrs,Cooking Wine For Cooking,Edible Flavoring Wine,Wine With Trace Salt Zhejiang Shanying Trading Co.,Ltd. , https://www.shanyingtrading.com