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Product Name:Golvatinib (E7050)
Synonyms:N-[2-Fluoro-4-[[2-[[[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl]amino]pyridin-4-yl]oxy]
CAS:928037-13-2
MF:C33H37F2N7O4
MW:633.6881864
Product Categories:Inhibitors
Density:1.408
Appearance:White powders
Purity:99%
Package:1kg/25kg/package
Uses:E7050 is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, respectively.
Uses:Golvatinib is a potent and orally available inhibitor of c-MET and VEGFR-2 that exhibits potential antitumor properties by suppressing the overexpression of these receptor tyrosine kinases.
Strongly inhibits the phosphorylation of c-Met and VEGFR-2. E7050 also potently inhibits c-met-proliferating tumor cells as well as HGF- or VEGF-stimulated endothelial cell growth. All exogenous and endogenous HGF-induced reversible, irreversible, and mutation-selective EGFR-TKIs in lung cancer cell lines that act on EGFR mutations are avoided in vitro by E7050 by blocking the Met/Gab1/PI3K/Akt pathway. E7050 can also prevent the gefitinib resistance of HCC827 cells due to the continuous action of HGF .
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S-23 Â CAS 1010396-29-8
AC-262536 Â CAS 870888-46-3
ACP-105 Â CAS 899821-23-9
China Recommend Antitumor Inhibitor CAS 928037-13-2 Golvatinib (E7050)
Product Name:Golvatinib (E7050)
Synonyms:N-[2-Fluoro-4-[[2-[[[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl]amino]pyridin-4-yl]oxy]
CAS:928037-13-2
MF:C33H37F2N7O4
MW:633.6881864
Product Categories:Inhibitors
Density:1.408
Appearance:White powders
Purity:99%
Package:1kg/25kg/package
Uses:E7050 is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, respectively.
Uses:Golvatinib is a potent and orally available inhibitor of c-MET and VEGFR-2 that exhibits potential antitumor properties by suppressing the overexpression of these receptor tyrosine kinases.
Strongly inhibits the phosphorylation of c-Met and VEGFR-2. E7050 also potently inhibits c-met-proliferating tumor cells as well as HGF- or VEGF-stimulated endothelial cell growth. All exogenous and endogenous HGF-induced reversible, irreversible, and mutation-selective EGFR-TKIs in lung cancer cell lines that act on EGFR mutations are avoided in vitro by E7050 by blocking the Met/Gab1/PI3K/Akt pathway. E7050 can also prevent the gefitinib resistance of HCC827 cells due to the continuous action of HGF .
 More products:
MK-2866/Ostarine CAS:1202044-20-9 / 841205-47-8
LGD-4033 CAS:1165910-22-4
GW-501516/Cardarine CAS:317318-70-0
MK-677 CAS:159752-10-0
MK-0773 CAS: 606101-58-0
GTX-007/S4/Andarine CAS:401900-40-1
SR-9009 CAS:1379686-30-2
SR-9011 CAS : 1379686-29-9
RAD-140 CAS:118237-47-0
YK-11 CAS:431579-34-9
GW-0742 CAS:317318-84-6
AICAR CAS:2627-69-2
GS5816 CAS:1377049-84-7
Sunifiram CAS: 314728-85-3
MK-1775 CAS 955365-80-7
S-23 Â CAS 1010396-29-8
AC-262536 Â CAS 870888-46-3
ACP-105 Â CAS 899821-23-9
China Recommend Antitumor Inhibitor CAS 928037-13-2 Golvatinib (E7050)
Model NO.: 928037-13-2
Alias: Golvatinib (E7050)
CAS: 928037-13-2
Appearance: White Crystalline Powder
Express Way: EMS, FedEx, TNT, DHL, Hkems, UPS
Trademark: WHSO
Transport Package: 10g/100g/1000g/Package
Specification: 99%
Origin: China
HS Code: 121425246
Model NO.: 928037-13-2
Alias: Golvatinib (E7050)
CAS: 928037-13-2
Appearance: White Crystalline Powder
Express Way: EMS, FedEx, TNT, DHL, Hkems, UPS
Trademark: WHSO
Transport Package: 10g/100g/1000g/Package
Specification: 99%
Origin: China
HS Code: 121425246
China Recommend Antitumor Inhibitor CAS 928037-13-2 Golvatinib (E7050)