NT3-chitosan can effectively activate endogenous nerves and repair the function of injured spinal cord

Researchers from Beijing University of Aeronautics and Astronautics, Capital Normal University, and Shanghai Jiaotong University have collaborated to achieve breakthrough results in spinal cord injury regeneration research and published articles in PNAS.

The neural stem cells (NSCs) in the adult mammalian central nervous system establish a new neural network through proper activation, differentiation and maturation, and integrate the repair function into the damaged nerve circuit, which is the key to nerve regeneration. However, the central nervous system damage microenvironment is often inhibited and inflammatory, limiting the ability of activated neural stem cells to differentiate into neurons and form new neural circuits.

The study used the Japanese MED64 in vitro multi-channel neuroelectrophysiological research system to detect neural circuits in acute spinal cord slices. It was found that by inserting NT3-chitosan into the 5-mm gap of the fully-cut and excised rat thoracic spinal cord, endogenous NSCs in the injured spinal cord can be strongly activated. By slowly releasing NT3, this biomaterial attracts NSCs to migrate to the injured area, differentiates into neurons, and forms a functional neural network that interconnects with the severed ascending and descending axons, restoring sensory and motor behavior. The study suggests that promoting endogenous neurogenesis would be a new therapeutic strategy for spinal cord injury.

The MED64 in vitro multi-channel neuroelectrophysiological research system is an electrophysiological signal recording system developed and produced by ALPHA MED SCIENTIFIC in Japan, which aims to help more researchers to improve the research in electrophysiology. The MED64 system is widely used in the study of central and peripheral nervous systems and the heart, and the MED64 system provides a good research method for both acute and cultured cell tissues. Especially in the case of acute slice signal recording, the MED64 system has an unparalleled low-noise electrode with built-in stimulator to make the synaptic potential more easily induced, and the user-friendly software interface allows users to have no worries about data processing.

Original address: NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury.October 12, 2015, doi: 10.1073/pnas.1510194112 PNAS October 12, 2015

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