ã€introduction】 Photothermia (PTT), as a non-traditional treatment of tumors, relies on a reagent that is strongly absorbed in the near-infrared to convert light energy into heat, thereby killing tumor cells. To date, many such agents have been developed for use in photothermal therapy. In addition, the researchers also found that combining imaging with photothermal therapy can greatly improve the targeting and sensitivity of cancer treatment. However, the biodegradability of inorganic nano-reagents that can achieve this function greatly hinders clinical development. Over the years, people have been working on a versatile biodegradable inorganic nano-reagent, the most common of which is ultra-small nanoparticles. Although it solves the problem of not being able to be discharged, most of the time it is greatly weakened by function. For the price. Therefore, the development of a biodegradable multifunctional inorganic nano-reagent is of great significance for the study of tumor diagnosis and treatment. [Introduction] Recently, Professor Liu Zhuang and Associate Professor Cheng Liang (Common Newsletter) of Suzhou University published a research paper entitled “Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics†at Angewandte Chemie International Edition, which reported a VS2 degradable nano-reagents, which use PEG-modified lipid vesicles to encapsulate VS2 nano-dots to prepare a nano-test VS2@lipid-PEG with both photothermal conversion and multi-mode imaging. The most important thing is that the reagent has Biodegradable without obvious toxic side effects. The authors used VS2@lipid-PEG nanoparticles to confirm in vivo magnetic resonance imaging, photoacoustic imaging and single electron emission computed tomography imaging based on VS2, and realized the application of VS2@lipid-PEG nanoparticles to multimode imaging. In photothermal therapy, the effect is remarkable. [Graphic introduction] Figure 1: Synthesis and characterization of VS2@lipid-PEG nanoparticles (a) Schematic diagram of the construction process of VS2@lipid-PEG nanoparticles; (b) TEM image of VS2 nanosheets; (c) TEM image of VS2@lipid-PEG nanoparticles; (d) UV-visible near-infrared absorption spectra of VS2 nanosheets and VS2@lipid-PEG nanoparticles; (e) Temperature rise curves of different concentrations of VS2@lipid-PEG nanoparticles under laser irradiation (808 nm, 0.6 W/cm2); (f) Photothermal conversion efficiency of VS2@lipid-PEG (200 mgmL-1) nanoparticles after 5 min of laser irradiation; (g) Photothermal stability of VS2@lipid-PEG (200 mgmL-1) nanoparticles under laser irradiation. Figure 2: In vivo multimodal imaging and photothermal therapy (a) Magnetic resonance T1-weighted image and r1 relaxation rate as a function of V molar concentration in VS2@lipid-PEG solution: (b) Magnetic resonance T1-weighted images of 4T1 tumor mice injected with VS2@lipid-PEG at different time points; (c) Quantitative comparison of magnetic resonance signals at the tumor at different time points; (d) Photoacoustic imaging (PA) of tumor mice before injection and after injection of VS2@lipid-PEG nanoparticles for 6 hours and 24 hours; (e) quantitative comparison of photoacoustic signals at tumor sites; (f) SPECT imaging of 4T1 tumor mice at different time points after injection of 99mTc-VS2@lipid-PEG (500 mCi); (g) Biodistribution of VS2@lipid-PEG nanoparticles in vivo after 24 hours of injection; (h) Infrared thermography image of laser irradiation after injection of VS2@lipid-PEG nanoparticles for 24 hours; (i) a graph of tumor temperature versus time for injection of VS2@lipid-PEG nanoparticles for 24 hours; (j) Tumor volume change curves of mice in different experimental groups after different treatments. Figure 3: In vivo clearance behavior and mechanism of VS2@lipid-PEG nanoparticles (a) Biodistribution of VS2@lipid-PEG nanoparticles in mice after 1, 7, 14, 30 days; (b) the mass of V measured in feces and urine after 1, 7, 14, and 30 days of injection; (c) UV-visible near-infrared absorption spectrum of VS2@lipid-PEG nanoparticles after exposure to air for 1, 7, 14, and 30 days; (d) Digital photos of VS2@lipid-PEG nanoparticles exposed to air for 1, 7, 14 and 30 days; (e) TEM images of VS2@lipid-PEG nanoparticles before and after 30 days of degradation; (f) XPS spectra of the new VS2@lipid-PEG nanoparticles; (g) XPS spectra of VS2@lipid-PEG nanoparticles after 14 days of degradation; (h) Schematic diagram of the mechanism of oxidation, degradation and discharge of VS2@lipid-PEG nanoparticles in vivo. ã€summary】 In this paper, a biodegradable inorganic nano-reagent based on VS2 was prepared and applied to multi-modal imaging and tumor photothermal therapy, which showed a good tumor treatment effect and promoted the development of tumor photothermal therapy research. team introduction: Professor Liu Zhuang received his bachelor's degree from Peking University in 2004. He received his Ph.D. from Stanford University in 2008. In June 2009, he joined the Institute of Functional Nano and Soft Materials of Suzhou University. In recent years, he has been engaged in research in the fields of nano biomedical materials and tumor nanotechnology. He has published more than 200 academic papers, with over 29,000 papers cited, and SCI H-index = 82. Funded by the Fund's Outstanding Youth Fund in 2012; 2013 In the year of 2015, he was selected as a national candidate for the Talent Project of 100 million talents; in 2015, he was funded by the National Outstanding Youth Fund; in 2015, he was selected as a “Young Talents†by the Ministry of Science and Technology; in 2016, he was selected as a “Young and Middle-aged Science and Technology Innovation Leader†by the Ministry of Science and Technology; He won the first prize of Jiangsu Science and Technology Award (the first person to complete) and the Biomaterials Science Lectureship in 2017. In 2015, he was invited to become Fellow of the Royal Society of Chemistry; in 2015 and 2016, he was selected as the “Highly Cited Researchers†(chemistry, materials) by Thomson Reuters; he was the deputy editor of Biomaterials magazine, an internationally renowned journal in the field of biomaterials. And several international mainstream journal editors. Associate Professor Cheng Liang received his Ph.D. from Suzhou University in June 2012 and stayed in school. In recent years, the main research direction is functional nanomaterial design and its application in biological imaging and cancer treatment. He has published more than 100 academic papers in international academic journals, including more than 40 papers by the first or correspondent authors, and some published in Chem Rev, Angew Chem, Adv Mater, ACS Nano, Adv Funct Mater, Biomaterials, etc. The paper has cited more than 6,000 times, with an H-index factor of 44, and has received funding from several research projects. 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