Release date: 2018-05-24 Science and Technology Daily, Washington, May 22 (Reporter Liu Haiying) Researchers at Brown University in the United States have found a new strategy to stimulate autophagy in cells by stimulating autophagy by inhibiting the expression of a protein called XPO1. They published a research paper in the Cell Report that the strategy could be used to treat Alzheimer's disease, amyotrophic lateral sclerosis (ALS) and other age-related neurodegenerative diseases. Autophagy is the process by which cells rebuild themselves by recycling their own cellular proteins or abrading organelles. In this process, the cells phagocytose these proteins or organelles and wrap them in vesicles called autophagosomes, which fuse with lysosomes to form autophagosomes that degrade the entrapment. Content, thereby achieving cellular metabolism and renewal of certain organelles. Studies have shown that many age-related diseases, including neurodegenerative diseases, are associated with autophagy dysfunction. The team led by Louis Lapierre, assistant professor of molecular biology at Brown University, found that inhibiting the expression of XPO1 in Caenorhabditis elegans increased the level of autophagy transcription factors in the nucleus, leading to autophagosomes, lysosomes and Increased autophagy lysosomes stimulate cell autophagy, which significantly increases nematode lifespan. A cancer drug, the selective nuclear export inhibitor (SINE), can be used as a drug to stimulate XPO1 and stimulate the autophagy strategy. Drosophila experiments have shown that SINE can prolong the lifespan of fruit flies suffering from ALS. Human cell experiments have shown that the effect of XPO1 inhibitors on autophagy in human cells is similar to that of nematodes. In human HeLa cells treated with SINE, the levels of autophagy transcription factors in the nucleus also increased, and the markers of autophagy activity such as autophagosomes and lysosomes also increased. The researchers say that XPO1 inhibitors can stimulate autophagy in human cells, but current research can only prove that this strategy can be used as a potential means to increase autophagy and treat age-related diseases, and they will pass more neurodegenerative disease models in the future. Test such drugs. Source: Technology Daily Acne Pimple Patch,Diy Pimple Patch,Pimple Band Aid,Peace Out Acne Dots Wenzhou Celecare Medical Instruments Co.,Ltd , https://www.celecaremed.com