Pharmacological effects 1. Anti-thrombotic effect: Radix Astragali decoction 15-20g (crude drug)/kg is given to the rats by gavage, so that the thrombus formation time is prolonged, the length is shortened, and the weight is reduced; prothrombin time and kaolin partial thromboplastin time Prolonged, euglobulin dissolution time shortened, indicating a significant inhibition of blood clotting. Radix Paeoniae extract 125-250mg (crude drug)/ml, in addition to prolonged prothrombin time, partial thromboplastin time, 250mg (crude drug) / ml also significantly inhibited thrombin agglutination of bovine fibrinogen, in 500 ~ 1000mg /ml is completely non-condensing. In addition, plasminogen can be activated to dissolve coagulated fibrin, and thus erythropolis exerts antithrombotic effects by inhibiting thrombin and activating plasminogen. Red peony extract (d-catechin, 200 mg/d-catechin) was given orally once daily for 46 consecutive days to significantly increase platelet aggregation time, platelet thrombosis time, and thrombus formation time in rats fed with high-fat diets. Prolonged, thrombus length and wet weight were significantly lower than in the control group. Red peony has improved blood rheological properties in hyperviscosity patients with coronary heart disease, resulting in lower blood viscosity at mid- and low-cutting speeds, prolonged red blood cell electrophoresis time, and reduced platelet aggregation. Herba Epimedii Tablets can make pulmonary arterial Whole blood viscosity, plasma viscosity, and hematocrit are significantly reduced in patients with heart disease. 2. Anti-platelet aggregation Paeoniae Radix extract significantly inhibited platelet aggregation induced by epinephrine, adenosine diphosphate (ADP), tip venom (TMVA), and arachidonic acid (AA) in vitro, and made platelets sticky. With the platelet activity of the third factor decreased, platelet cAMP content increased. Radix Paeoniae Rubra and its derivatives 801 and 802 inhibited ADP and collagen-induced platelet aggregation in rabbits at 5×10-4 to 5×10-3 ml/L, and 802 had the strongest effect on ADP induction. There is still depolymerization of platelet aggregation. The anti-platelet aggregation effects of 3 drugs are in line with the effects of reducing hepatic mitochondrial oxygen consumption, respiratory control rate, and reducing the ratio of phosphorus/oxygen (P/O), indicating that the 3 drugs have antiplatelet effect and interfere with the energy metabolism of platelets. related. Red peony inhibited the biosynthesis of thromboxane A2 (TXA2)-like substances during the incubation of rabbit platelet-rich plasma (PRP) with AA, and the shrinkage of its products on rabbit aortic strips was significantly reduced, indicating that erythromycin inhibits platelet aggregation and It is related to the pro-aggregation effect of TXA2. Coronary heart infusion TPG to make fine angina platelet aggregation percentage expansion and significantly reduced the number of aggregation, it can show higher surface activity and platelet aggregation significantly reduced. Above experiments show that the mechanism of platelet aggregation inhibition Radix possible interference platelet energy metabolism, inhibition of the biosynthesis of TXA2 and platelet cAMP levels increase and so on. 3. Hypolipidemic and anti-arteriosclerotic effect of red peony extract tablets 5g (crude drug)/kg, once a day, once every 10-15 weeks, so that plasma cholesterol (Tch), triglyceride (TG) in hyperlipidemic rabbits , Low density lipoprotein cholesterol (LDL-Ch), Very low density lipoprotein cholesterol (VLDL-Ch) decreased significantly; High density lipoprotein cholesterol (HDL-Ch) and HDL2-Ch were significantly higher than those of the control group; Tch/HDL- Ch, Tch/HDL2-Ch, LDL-Ch/HDL-Ch and LDL-Ch/HDL2-Ch ratios were significantly reduced, and the ratio of thromboxane A2/prostaglandin (TXA2/PGI2) caused by hyperlipidemia tended to increase. normal. In addition, plasma lipid peroxide (LPO), arterial wall lipids, calcium and phospholipids, and aortic plaque area can be reduced. The mechanisms of anti-arteriosclerosis in radix paeoniae may improve the ratio of lipoprotein components, decrease plasma lipid peroxide, decrease calcium deposition on arterial wall, inhibit platelet aggregation, regulate TXA2/PGI2 balance, and activate adenylate cyclase to increase arterial Intracellular cAMP concentration and so on. 4. Effects on Cardiovascular System Radix Paeoniae Rubra (Grass-Tobacco) decoction slightly inhibits isolated heart and rabbit heart, low-dose (l: 0.5, 0.05ml), and slows down the heart rate and reduces the amount of stroke. Large doses (1:0.5, 0.15 ml) were significantly inhibited and had conduction block. Vascular perfusion caused mild dilation of the blood vessels of the viscera, hindlimbs, and isolated rabbit ears. Perfusion of isolated rat hearts with 0.2% Chishao injection increased coronary flow by 28.4%. Arterial injection to anesthetized dogs also increased coronary flow. In addition to increased coronary flow, intravenous injection also reduced peripheral resistance and blood pressure; these effects were not affected by reserpine pretreatment, and may have a direct effect. Mice were injected intraperitoneal injection Radix, myocardial 86Rb uptake increased, indicating myocardial nutritional blood flow, this effect can be suppressed propranolol, showed the β- receptors. In the early stage of heart failure after burns in rats, Chihong injection 10g (crude drug) / kg gavage, there is a certain ease and improvement. Intramuscular injection of Chishao Injection 1g/kg has therapeutic and preventive effects on experimental pulmonary hypertension rabbits, which results in pulmonary vasodilation, improved pulmonary blood flow, decreased pulmonary artery pressure, increased cardiac output, and improved cardiac function. Red peony root injection also has the effect of expanding pulmonary blood vessels in patients with pulmonary heart disease, reducing pulmonary artery pressure and pulmonary vascular resistance, increasing cardiac output, and improving right heart function and blood rheology. Herbal medicine extract tablets have similar effects on patients with pulmonary heart disease. Red peony root injection 40g (crude drug) / kg and 80g (crude drug) / kg intraperitoneal injection, significantly prolonged survival time of normoxic hypoxia in mice. Intravenous injection of 8g/kg had obvious protective effect on acute myocardial ischemia induced by pituitrin. 40 g/kg gavage can also prolong the survival time of decompression and hypoxia in mice. 5, anti-tumor effect red peony butanol extract (erythroquinone D) 1 ~ 2g/kg intraperitoneal injection, the inhibition rate of mouse S180 solid tumor was 31% -49%. The red peony root water extract (Erythrochlor A) or 70% ethanol extract (Erythroquinone C) alone had no significant effect on S180 solid tumors. When combined with subthreshold doses of cyclophosphamide, it had significant inhibition; A, C no significant effect on 615 mouse leukemia, but combined with low-dose methotrexate can significantly prolong the survival of 615 leukemia mice. The cAMP content in tumor tissues was significantly lower than that in normal tissues. Red peony A, C, and D increased cAMP levels in S180 solid tumors, S180 ascites carcinoma, or Lewis lung cancer tissues, which may be associated with anti-cancer or anti-cancer synergism. related. In S180 solid tumor mice, the plasma fibrin content was 2-3 times higher than normal, and Astragalus membranaceus A2g/kg intraperitoneal injection can significantly reduce it, and this effect may also be related to anti-cancer effect. Red peony A or C alone promotes the spontaneous metastasis of Lewis lung cancer, but low-dose cyclophosphamide also has no significant effect, but combined with red peony A can significantly reduce this lung metastasis. 6. Liver protection effect of Radix Paeoniae Rubra was 3.3 mg/ml, 1.67 mg/ml, and 0.7 mg/ml, which significantly promoted the DNA synthesis of hepatocytes in vitro and had a good effect on hepatocyte regeneration and liver function recovery. Intravenous injection of Chishao Injection 3.75g/kg had obvious protective effect on liver injury induced by D-galactosamine in rats, which increased the survival rate of animals, and the liver atrophy and alanine aminotransferase were significantly lower than that of the control group. The major opsonin of the nuclear-macrophage system was higher than the control group. The hepatoprotective mechanism may be to increase the level of plasma fibronectin (PFN) in rats, thereby enhancing the phagocytic function of the reticuloendothelial system and enhancing the activity of prime factors to protect the liver cells, prevent liver damage and promote hepatocyte regeneration. Intraperitoneal injection of Radix Astragali 801 and 24mg/kg once a day for 2 weeks has a significant effect on the activity of carboxysterase (CEase) in liver and heart of rats. This action can promote the hydrolysis process in vivo and promote the excretion of toxic substances in vivo. The role. Intraperitoneal injection of d-catechin 100mg/kg or 50mg/kg had protective effects on alcohol-induced acute mitochondrial damage in mice, reduced lipid fluidity of hepatic mitochondrial membrane in model animals, and increased hepatic mitochondria reduced glutathione (GSH) content, reduces Ca + leaf uptake and lipid peroxide production, relieves acute damage to liver mitochondrial membrane structure by counteracting the toxin action of ethanol. 7. Other effects of erythrosine gallic acid derivative Gallic acid propyl ester has the ability to scavenge oxygen free radicals, can significantly inhibit the mitochondrial swelling and lipid peroxidation induced by ferrous sulfate and Vitamin C, and can protect the structure and function of mitochondria. normal. Radix Paeoniae Rubra has no significant effect on normal isolated guinea pig ileum, but it can relieve intestinal fistula caused by acetylcholine. Radix Astragali butanol extract 3g/kg subcutaneous injection can promote the phagocytic function of the reticuloendothelial system, increase liver weight, no significant effect on hemolysin production and delayed type hypersensitivity. The extract of Rhizoma Chuanxiong has a significant inhibitory effect on β-hydroxy-β-methylglutaric acid coenzyme A and calcium channel blocker receptors. Red peony has a strong inhibitory effect on Shigella, Salmonella typhi, and hemolytic streptococcus in vitro. Grass gill herb decoction gavage can temporarily increase blood glucose in rabbits. Narrow-leaf gills-alcohol extracts have significant sedation and certain analgesic effects, and can also increase gastric acidity, increase appetite and digestive function. The medicinal value of red peony Red peony can cure, relieve pain, cooling blood, swelling. Treatment of irregular menstruation, amenorrhea, desirable red peony 12 grams, Angelica 12 grams, Rehmannia 12 grams, Chuanxiong 6 grams, Shuijianbi. Treatment of mastitis, desirable red peony 100 grams, raw licorice 50 grams, Shuijianbi, 1 day, 2 times service. In addition, treatment of melasma, peony flowers can also be used 30 grams, 30 grams of almonds, Angelica 30 g, 30 g white silkworm, melon child 60 g, were very fine, 5 grams, was added water into a paste, Fumian 10 minutes, 1 night, there is the role of cleansing freckle. Aspirin [Aspirin, 2-(acetoxy) benzoic acid, also known as acetylsalicylic acid] is a white crystal or crystalline powder, odorless or slightly acetic acid odor, slightly soluble in water, easily soluble in ethanol, can be Soluble in ether and chloroform, the aqueous solution is acidic. This product is a derivative of salicylic acid. After nearly a hundred years of clinical application, it has been proved that it has a good effect on relieving mild or moderate pain, such as toothache, headache, neuralgia, muscle pain and dysmenorrhea. It is also used for colds, flu, etc. Relieving fever of febrile diseases, treating rheumatism and so on. In recent years, it has been found that aspirin has an inhibitory effect on platelet aggregation and can prevent thrombosis. It is clinically used to prevent transient ischemic attack, myocardial infarction, artificial heart valve and venous fistula or other postoperative thrombosis. Anti-inflammatory effects of drugs, antipyretic and analgesic effects and aspirin SHAANXI HAIBO BIOTECHNOLOGY CO., LTD , https://www.rozenbio.com