Seize the billion-dollar precision medical market: tumor detection will become the next clinical explosion

Many people know about genetic testing because they have pregnant mothers and do non-invasive prenatal genetic testing (NIPT) to predict the health of the fetus. This product enables major gene sequencing companies to take the lead in testing water clinical care , and to go through regulation and enter the commercial channel. Since 2011, more than two million pregnant women in China have used this genetic testing product.

Of course, there are many clinical applications of genetic testing, such as detection of neonatal genetic diseases, detection of deafness genes, and detection of individualized therapeutic genes such as tumors and cancer. It is only these applications that want to enter the clinical medical market, it will take some time to break through.

The industry believes that the emergence of genetic testing will lead the individual medical revolution, the medical market for genetic testing is a 100 billion-scale cake. However, genetic testing companies need to go through supervision, the cost of testing needs to be further reduced, products can enter various medical institutions, and ordinary people have a deeper understanding of genetic testing. To meet these conditions, the genetic industry can see the light.

History of non-invasive prenatal genetic testing

NIPT takes 5 ml of peripheral venous blood during the specific pregnancy period of pregnant women, and uses a new generation of DNA sequencing technology to sequence the fetal free DNA fragments in the plasma to determine the fetal chromosome aneuploidy disease (21-trisomy synthesis). The risk rate of Zheng, 18-trisomy syndrome and 13-trisomy syndrome, the current accuracy rate is 99.9%, the price is 855 yuan (Shenzhen is the lowest price in the country) -2500 yuan. The emergence of non-invasive prenatal genetic testing has prevented older women from avoiding the 0.5% risk of miscarriage caused by amniocentesis.

Prior to the emergence of NIPT, domestic prenatal screening and diagnosis methods were relatively backward, first through screening for pregnant women at 11 and 13 weeks of gestation, followed by early pregnancy and mid-term Down's screening for Down's screening. High-risk pregnant women undergo amniocentesis and prenatal diagnosis, followed by B-ultrasound. This method has a positive effect but has its drawbacks.

Zhao Lijian, deputy general manager of Huada Co., once pointed out in a share that the prevalence rate of serological screening is 66% to 83%, accompanied by a false positive rate of more than 5%, and there is a traumatic prenatal diagnosis. Come to a certain risk of miscarriage and suffocation.

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