Release date: 2014-09-15 Recently, in a research paper published in the international magazine Stem Cells, researchers from the Salk Institute successfully converted human skin cells into human transplantable white blood cells for the first time. It is well known that white blood cells are the body's immune system. Warrior, which protects the body against infections and foreign invaders. Researcher Juan Carlos Izpisua Belmont said the study may provide new ideas and hopes for the development of new therapies to introduce new white blood cells into the body to treat diseases such as cancer. Researchers in the mouse body have found that the process of transforming into white blood cells is very rapid and safe. This method bypasses the long-standing research obstacles and provides new clues for the development of recombinant regenerative therapy for human cells. Blood cells produced by induced pluripotent stem cells are often unable to be transplanted into organs or bone marrow, and they may also cause tumorigenesis; the new technique called indirect lineage transformation developed by researchers in this study takes only two weeks. It doesn't produce extra tumor tissue; the researchers say that we will make skin cells "forget" their own properties and then transform them into the cell types we need, and in this study we let them succeed. Transformed into white blood cells. The indirect lineage transformation technique developed by the researcher Belmont can be used to make human vascular cells, a technique that uses a molecule called SOX2 to make it plastic, that is, to lose its memory into a particular cell type, followed by The researchers asked a genetic factor called miRNA125b to induce cells to turn into white blood cells. This study has taken a new step in the research of successful stem cell transplantation for the treatment of human diseases in the future. Source: Bio Valley
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Scientists successfully convert human skin cells into white blood cells for the first time
Recently, in a research paper published in the international magazine Stem Cells, researchers from the Salk Institute successfully transformed human skin cells into human transplantable white blood cells for the first time.