Release date: 2016-07-20 A novel minimally invasive treatment procedure is effective for many patients with Fuchs corneal endothelial dystrophy eye disease, has no side effects, has low cost of care, and does not require a corneal transplant. New method without corneal transplantation Fuchs corneal endothelial dystrophy eye disease (FED) is the most common disease requiring corneal transplantation in the United States. In the Corneal Journal, a research paper led by Professor Catherine Corby Louis Bullock, chair of the Visual Ophthalmology Chair at the University of Chicago, published a research paper. This paper shows that after removing a few square millimeters of monolayers on the inside of the cornea, the surrounding tissue can be regenerated without the need for a corneal transplant. This simple procedure can repair the vision of three-quarters of patients with FED. In the past two years, Colby has performed a new treatment program at Harvard Medical School called the post-corneal elastic layer peeling. This treatment was performed in 11 patients between the ages of 51 and 91. Two of the patients were treated on both eyes. In the evaluation six months after surgery, the corneas of 10 eyeballs became clear and clear (77%); 8 eyes had 20/20 (equivalent to 1.0) or better vision (two patients had retinal diseases) , limiting their final vision); the other three eyes did not respond and required a standard corneal transplant. “It’s too early to call this treatment,†Colby said. “We just had the first surgery two years ago. But when it works, it’s great! It’s cheap and fast, It also saves the local immunosuppression that patients need to receive other people's body cells." Effect of post-corneal elastic layer dissection The first patient to receive post-corneal elastic layer dissection was 69-year-old Eric in the Boston area. Thorpe. Very happy, he said: "This is really a big breakthrough. My eye now has 20/20 vision, which is equivalent to a boy's vision. It is really amazing." He added: "Be the first. The healer is really honored, it is worth it." Post-corneal elastic layer dissection involves removal of a small piece of corneal endothelial cells that connect the underlying layer (post-corneal elastic membrane), a patient with Fuchs corneal endothelial dystrophy eye disease, in which water accumulates in the cornea. In the front window of the eye, due to dysfunction of pumping cells, vision loss, glare, and halo are caused. If left untreated, the condition will deteriorate into painful blindness. Removal of central dysfunctional cells allows healthy peripheral cells to metastasize to the corneal center where they regain drainage and remove effusion from the membrane, which gradually restores vision. "Although post-corneal elastic layer peeling is a relatively simple procedure, and its potential is revolutionary." Colby said that in 2015, there were 14,000 corneal transplants in the United States, only for Fuchs corneal endothelium nutrition. Bad eye disease, which is the most common cause of corneal transplantation. This kind of transplant is very effective, but the transplanted tissue is expensive, and the supply is limited in some parts of the world. Because the corneal tissue is foreign, patients must use steroids to suppress their immune response and prevent rejection of transplanted cells. Steroids can cause glaucoma, cataracts, and infection. The researchers divided the patients into four groups based on their response to post-corneal elastic layer peeling surgery. Those who responded quickly recovered their vision within one month after surgery. Normal patients recovered their vision within three months. Those who responded slowly required more than three months of repair. Non-responders had persistent corneal edema and needed a simplification. Corneal transplant surgery. Thorpe was the first patient to receive treatment. The eye was foggy during the recovery and lasted for nearly a year, which prevented him from driving. The eye slowly recovered, but the other eye started in 2013. Vision gradually declines. Colby provided her new treatment program and explained the underlying cause mechanism. Thorpe had great confidence and understanding for her. He volunteered to be the first healer. "It is certainly worth it. This operation took less than 30 minutes." He recalled, "Some things let you know that your vision is constantly "Down," Thorpe responded. "When you gradually lose sight, your world is constantly shrinking. But after my surgery, my world is gradually expanding. Overnight and night, the world is constantly becoming clear, like the fog of London. This is great!" Source: Bio-Exploration
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