Why do you have to eat more cold, how hot is it when you have a fever? October 08, 2016 Source: Bio Valley Recalling what was the last time you caught a cold and what was the taste of illness? For many people, the feeling of illness is a series of psychological and behavioral changes, including fatigue, drowsiness, altered appetite, changes in sleep patterns, and the desire to stay away from others. Of course, there is no change that makes people feel so wonderful, but if we recover from the disease, we will be refreshed. More interestingly, some behavioral changes induced by infection are collectively referred to as “disease behaviorsâ€, which occur in many animals, from our pet dogs, pet cats to back garden worms, because so many animals Symptoms of disease behavior change during infection, so scientists have found through long-term research that these behaviors actually protect us from infection. At Yale University's immunobiology lab, researchers are very interested in researching disease behavior, and they have recently turned their attention to the study of why appetite is missing during infection, if all disease behavior can help us avoid it. If you are infected, why is there a loss of appetite? A common theory is that although we will starve ourselves, hunger is more lethal to viruses or bacteria than ourselves, and some scientific research supports this claim, but many studies have denied it. . So the researchers recently plan to start researching again why we have a loss of appetite during illness. Why does the body cause loss of appetite when infected? When we are sick, whether we have an appetite at home or in the hospital, we will be discussed frequently. Of course, each family has its own secret recipe to solve the problem of loss of appetite during family members' infection. Some people think that if you want to eat, you should eat some food, and you should be well-nourished. Some people believe that the old saying goes, "It’s a cold to eat more, a fever is more hungry," but few people suggest that he should be determined according to the appetite of the individual patient. / Her food intake, so determine the best method or factor or help people recover from mild infections. In addition, it is more important to understand the cause of changes in the body's appetite during infection or to help improve the survival of critically ill patients. Critically ill patients usually do not eat on their own, so doctors need to feed them during their illness. But how much food is the most appropriate amount? Which kind of food is best for patients? A series of questions are worthy of continuous exploration and research by doctors. Of course, doctors have also conducted many clinical trials to detect different feeding systems, but today there is no conclusion. If we can understand the role of appetite in the body's infection process, then we may be able to provide more rational care for home or inpatients. Is it a good thing to lose appetite when we are sick? Like humans, laboratory mice lose their appetite when infected, and mice die frequently when infected with Listeria monocytogenes and fed mice; however, when infected with influenza virus and When the mice were fed, the former would live better than the unfed mice, so the above two cases formed a sharp contrast. More interestingly, when researchers use the components of the cell wall to replace live bacteria or replace the living virus with synthetic viral components, they can still find the same effect, and these components are able to be in the cells of the virus and bacteria. Found separately, this suggests that the reverse effects of feeding observed by researchers may extend to many bacteria and viruses. The researchers also found that glucose in food is primarily responsible for feeding effects, and that these effects are reversed when researchers block the ability of cells to utilize glucose through 2-deoxyglucose or D-mannoheptulose. Why does diet show different mechanisms influencing bacterial and viral infections? Surviving in infection is a very complicated process involving many factors. During the infection, there are two things that cause damage to the body. The first is the direct damage of the organism to the body, and the other is the immune response. Indirect damage. The early defense mechanisms of the immune system are relatively non-specific, and are considered "grenade" rather than "sniper rifles", which is why the immune system damages other parts of the body to effectively remove the infection in order to counteract this effect. Tissues in the body create a mechanism to detoxify or defend against virulence factors to help the immune system clear out foreign invaders, and the ability of the organization is called "tissue tolerance." In a recent study, the researchers found that tissue tolerance to bacterial and viral infections may require different metabolic energy sources, and ketone bodies act as an energy source for the liver during prolonged fasting, which can help protect against antimicrobials. Indirect damage caused by immune response. In contrast, when we eat, the body's rich glucose may help the body to resist the indirect damage caused by the anti-viral immune response. What does this mean for humans? Essentially, mice are different from humans, and many of the potential therapies in mouse models cannot be applied to the human body. The concepts we discuss here need to be confirmed multiple times in human organisms. In the article, the researchers revealed the body's choice of food during the disease. So far, nutritional choices, especially for critically ill patients, are actually arbitrarily chosen, and many people are based on the type of patient's organ failure. Make a choice. The researchers pointed out that it may be more important that the choice of nutrition for critically ill patients depends on the disease the patient is infected with. For less serious infections, what we want to eat may be in our own way. We choose to better respond to infections. This may be what we often say, “get more cold, eat more hungry.†Maybe Grandma knew that different infections require different types of nutrition to help us recover early, or they know if If we have a specific way of doing things, honey tea may be the best for us, or chicken soup; researchers hope that with the deepening of later research work, they can apply more research results to the human body. 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