New treatment for common eye diseases: no need for corneal transplantation

A novel minimally invasive treatment procedure is effective for many patients with Fuchs corneal endothelial dystrophy eye disease, has no side effects, has low cost of care, and does not require a corneal transplant.

New method without corneal transplantation

Fuchs corneal endothelial dystrophy eye disease (FED) is the most common disease requiring corneal transplantation in the United States. In the Corneal Journal, a research paper led by Professor Catherine Corby Louis Bullock, chair of the Visual Ophthalmology Chair at the University of Chicago, published a research paper. This paper shows that after removing a few square millimeters of monolayers on the inside of the cornea, the surrounding tissue can be regenerated without the need for a corneal transplant. This simple procedure can repair the vision of three-quarters of patients with FED.

In the past two years, Colby has performed a new treatment program at Harvard Medical School called the post-corneal elastic layer peeling. This treatment was performed in 11 patients between the ages of 51 and 91. Two of the patients were treated on both eyes. In the evaluation six months after surgery, the corneas of 10 eyeballs became clear and clear (77%); 8 eyes had 20/20 (equivalent to 1.0) or better vision (two patients had retinal diseases) , limiting their final vision); the other three eyes did not respond and required a standard corneal transplant.

“It’s too early to call this treatment,” Colby said. “We just had the first surgery two years ago. But when it works, it’s great! It’s cheap and fast, It also saves the local immunosuppression that patients need to receive other people's body cells."

Effect of post-corneal elastic layer dissection

The first patient to receive post-corneal elastic layer dissection was 69-year-old Eric in the Boston area. Thorpe. Very happy, he said: "This is really a big breakthrough. My eye now has 20/20 vision, which is equivalent to a boy's vision. It is really amazing." He added: "Be the first. The healer is really honored, it is worth it."

Post-corneal elastic layer dissection involves removal of a small piece of corneal endothelial cells that connect the underlying layer (post-corneal elastic membrane), a patient with Fuchs corneal endothelial dystrophy eye disease, with water accumulating in the cornea. In the front window of the eye, due to dysfunction of pumping cells, vision loss, glare, and halo are caused. If left untreated, the condition will deteriorate into painful blindness.

Removal of central dysfunctional cells allows healthy peripheral cells to metastasize to the corneal center where they regain drainage and remove effusion from the membrane, which gradually restores vision.

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