China's first super bacterial vaccine approved clinical study July 27, 2015 Source: Xinhuanet Recently, the first super bacterial vaccine, the recombinant Staphylococcus aureus vaccine, jointly researched by the Third Military Medical University and the local science and technology company, was approved by the State Food and Drug Administration for Phase I, II and III clinical studies, marking the study. Significant milestones have been achieved. "Superbug" refers to a variety of drug-resistant bacteria that appear clinically and is resistant to many antibiotics. In our country, the total amount of antibiotics used by 1.3 billion people is half that of the 6 billion people in the world. The World Health Organization study pointed out that if "super bacteria" are not effectively contained, the resulting death toll may increase by 10 million people worldwide each year. Staphylococcus aureus (S. aureus) is one of the "superbugs" with the highest rates of trauma, burns, community and hospital infections in the military. Since 2008, Zou Quanming led the team of more than 30 experts including Zeng Hao, Tong Wende, Guo Gang, Wu Chao, Zhang Jinyong, Gu Jiang, Liu Kaiyun and Zhang Weijun, and initiated the research and development of the Staphylococcus aureus vaccine. After 8 years of cooperation with local technology companies, we have mastered the latest “anti-artifact†for vaccine development – ​​reverse vaccinology technology, and completed a difficult and promising preclinical study of the original Staphylococcus aureus vaccine in a short period of time, from thousands Among the candidate components, the "effective components" of the vaccine were screened, and the number of experimental animals used was more than 16,000. In order to investigate and study the safety of this vaccine, Zou Quanming and the team members took the lead in injecting the first Staphylococcus aureus vaccine before conducting clinical trials. According to Professor Zou Quanming, the Staphylococcus aureus vaccine contains protective immune components against five targets, which can play an exact role in blocking important metabolic pathways of bacteria, inhibiting adhesion and colonization, controlling toxin spread, and breaking immune escape. "A large number of repeated animal immune challenge protection experiments have proved that the vaccine protection rate is greater than 85%, which can effectively resist the infection of Staphylococcus aureus, laying a solid scientific foundation for human clinical trials." The most common waxy and sweet corn market, waxy corn has higher nutrient content than ordinary corn, containing 70-75% starch (and almost all amylose), more than 10% protein, 4-5% fat and 2 % Of multivitamins have more grains, VA, VB1, and VB2 than rice with the highest content of protein, fat and VB2. Yellow corn also contains carotenoids, such as rice and wheat. The molecular weight of waxy corn starch is more than 10 times smaller than that of ordinary corn. The starch makes glutinous rice sticky and softer than ordinary hard corn. Its digestibility is more than 20% higher than that of ordinary corn, and it is suitable for people with irregular teeth. At the same time, the content of amylose (a kind of polysaccharide) is very high, which is not suitable for diabetics.
Waxy corn is also called sticky corn. The grains have rough, waxy endosperm, similar to shiny, transparent grains, such as hard and dented corn. Its chemical and physical properties are controlled by a recessive gene located on chromosome 9. 100% of the starch in the endosperm is amylose.
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