Life-saving medicine turns into a life-threatening drug PI3K inhibitor to promote cancer cell metastasis July 08, 2015 Source: Medical Network PI3K is a protein kinase. Many studies have found PI3K abnormalities in various types of human cancers, which has attracted the interest of many scientists. Many kinds of PI3K inhibitor drugs have been developed with PI3K as a therapeutic target. The development is in a different stage of clinical validation. However, based on the current results, the PI3K inhibitor drug is not ideal in clinical application, and has no significant effect on improving the survival rate of cancer patients. Anti-Impact Tpr Gloves,Anti Impact Gloves,Impact Resistant Gloves,Anti Vibration Impact Gloves Jiangsu Hespax Security Co., Ltd , https://www.hespax.com
Life-saving medicine turns into a life-threatening drug PI3K inhibitor to promote cancer cell metastasis
Recently, scientists from the Wistar Institute in the United States conducted a new study. They found that the use of PI3K inhibitors alone for cancer treatment may promote the aggressiveness of tumor cells and the spread to other organs, leading to a worsening of the patient's condition. Recently, the research results of this research were published in the international academic journal PNAS.
In this study, the researchers focused their research on the "energy plant" of cells, mitochondria, how mitochondria reprogram in tumor cells treated with PI3K inhibitors, and how mitochondrial changes prevent targeted drugs from functioning effectively. . The researchers found that cells treated with no inhibitor drugs have mitochondria distributed around the nucleus, while treatment of tumor cells with PI3K inhibitors causes mitochondria to move to specific regions of the cell membrane. The important "strategic" position of mitochondria occupying the surrounding cell skeleton can be cells. Migration and invasion provide a lot of energy, which indicates an increase in cell movement and invasion.
Overall, the findings of this study contradict the expected effects of PI3K inhibitor drugs, which may promote tumor metastasis and invasion, and this process relies on mitochondrial functional responses, thus developing PI3K inhibition. Drugs may also need to take into account changes in the functional response of mitochondria, and develop new drug combinations to treat cancer in conjunction with changes in mitochondria.